{"id":"W1496388003","doi":"10.1593/neo.13678","title":"RNF115/BCA2 E3 Ubiquitin Ligase Promotes Breast Cancer Cell Proliferation through Targeting p21Waf1/Cip1 for Ubiquitin-Mediated Degradation","year":2013,"lang":"en","type":"article","venue":"Neoplasia","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Sun Yat-sen University Cancer Center","keywords":"Ubiquitin ligase; Small interfering RNA; Ubiquitin; Gene silencing; Cell growth; Cancer research; Gene knockdown; Cell biology; Chemistry; Estrogen receptor; Deubiquitinating enzyme; Cyclin D1; Cell; Breast cancer; Cell cycle; Cancer; Biology; Transfection; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002960235,0.0004132357,0.0004730739,0.0001033183,0.0002809479,0.0001154563,0.0001433631,0.0003586969,0.0009660858],"category_scores_gemma":[0.000321396,0.0003901299,0.0001840959,0.0003514552,0.0000719626,0.0005741438,0.00005391342,0.0004345084,0.0002382104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004689604,"about_ca_system_score_gemma":0.0005586104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182518,"about_ca_topic_score_gemma":0.0003748118,"domain_scores_codex":[0.9973599,0.0001011265,0.0006770815,0.0006638006,0.0004887295,0.0007094158],"domain_scores_gemma":[0.9981426,0.0001561202,0.0003590872,0.0003953949,0.0006875014,0.0002593243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006064459,0.0006354266,0.003562317,0.001065966,0.0001936047,0.00003555693,0.002953036,0.000139462,0.9132371,0.000235158,0.05772402,0.01961189],"study_design_scores_gemma":[0.006911553,0.0008353981,0.004705994,0.0006598685,0.0004297619,0.0002450433,0.0009698545,0.01528047,0.955818,0.0003014907,0.0130368,0.0008057824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784828,0.001219068,0.004829071,0.005493224,0.0006742089,0.005426606,0.0003229801,0.0004861678,0.003065818],"genre_scores_gemma":[0.9863666,0.0002068539,0.006512014,0.001244918,0.0009872125,0.001928639,0.001429505,0.0001528085,0.001171442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04468722,"threshold_uncertainty_score":0.9999472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228996384673211,"score_gpt":0.2547502788589614,"score_spread":0.2424603150122293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}