{"id":"W1496540099","doi":"10.4049/jimmunol.0802491","title":"Conditional Inactivation of TACE by a <i>Sox9</i> Promoter Leads to Osteoporosis and Increased Granulopoiesis via Dysregulation of IL-17 and G-CSF","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute of General Medical Sciences","keywords":"Granulopoiesis; Bone marrow; Haematopoiesis; Osteoclast; Spleen; Lymphopoiesis; Biology; Endocrinology; Population; Osteoblast; Cre recombinase; Internal medicine; Cancer research; Immunology; Cell biology; Medicine; Stem cell; In vitro; Genetically modified mouse; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005089798,0.00008414432,0.0003036277,0.0002136627,0.00004300728,0.000004445821,0.00008070311,0.00007863573,0.00006213465],"category_scores_gemma":[0.0002154345,0.00005836699,0.00003778353,0.0001762367,0.0002089733,0.00008963876,0.00003471487,0.0001879433,9.06169e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004316978,"about_ca_system_score_gemma":0.00005891457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004187045,"about_ca_topic_score_gemma":0.000002367505,"domain_scores_codex":[0.9989693,0.0001725383,0.0004006372,0.00007426841,0.0002682775,0.0001150155],"domain_scores_gemma":[0.998885,0.0002020512,0.0003311454,0.0001334943,0.0003932604,0.00005505914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001953528,0.0001279529,0.001283738,0.00002471353,0.00006227564,0.000002894759,0.0004715021,0.000002747026,0.9889156,0.00002614664,0.0008706781,0.006258269],"study_design_scores_gemma":[0.001915802,0.002969516,0.2941948,0.00008725862,0.00009154122,0.0004524823,0.0002008959,0.00003442154,0.6990851,0.0006798044,0.0002372574,0.00005112961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933125,0.0006480783,0.0006900783,0.005020965,0.00001343048,0.0002160261,0.000009532961,0.000002660191,0.00008676814],"genre_scores_gemma":[0.9988839,0.0001957107,0.0005202112,0.0002532745,0.00001801546,0.000001236079,0.00001228583,0.000006641409,0.0001087204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2929111,"threshold_uncertainty_score":0.2380137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008357323446455608,"score_gpt":0.2627258689433143,"score_spread":0.2543685454968587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}