{"id":"W1496540099","doi":"10.4049/jimmunol.0802491","title":"Conditional Inactivation of TACE by a <i>Sox9</i> Promoter Leads to Osteoporosis and Increased Granulopoiesis via Dysregulation of IL-17 and G-CSF","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute of General Medical Sciences","keywords":"Granulopoiesis; Bone marrow; Haematopoiesis; Osteoclast; Spleen; Lymphopoiesis; Biology; Endocrinology; Population; Osteoblast; Cre recombinase; Internal medicine; Cancer research; Immunology; Cell biology; Medicine; Stem cell; In vitro; Genetically modified mouse; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001541966,0.0004819558,0.0002582235,0.0004362319,0.0001578537,0.0003468051,0.0002738161,0.0003286654,0.002006625],"category_scores_gemma":[0.0001052023,0.0002666311,0.0002952869,0.0001853982,0.0004428534,0.0001337212,0.0002582136,0.0006484557,0.0005864204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002007062,"about_ca_system_score_gemma":0.0002008808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000750859,"about_ca_topic_score_gemma":0.00103661,"domain_scores_codex":[0.9997278,0.00002930967,0.00003910952,0.00006075631,0.00008165003,0.00006141933],"domain_scores_gemma":[0.9996881,0.00003681295,0.0001441973,0.00002669323,0.00001731061,0.00008688919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006407303,0.00001978634,0.000165862,0.00001170279,0.000003796047,0.0001250144,0.000008116288,0.00003160995,0.999106,0.00006450817,0.00001814904,0.000381373],"study_design_scores_gemma":[0.00004043887,0.0001973065,0.007958313,0.000009055045,0.00003209154,0.0009022574,0.00003503984,0.0012415,0.9874395,0.00004887657,0.002088352,0.000007228749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926352,0.0004969644,0.004606107,0.00008739645,0.00003462263,0.00002989241,0.0008197264,0.0002000477,0.001089947],"genre_scores_gemma":[0.9910275,0.0004748913,0.002096081,0.00005069847,0.0000150164,0.00004081514,0.0009881306,0.00007674662,0.005230217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006625,"threshold_uncertainty_score":0.006712794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008357323446455608,"score_gpt":0.2627258689433143,"score_spread":0.2543685454968587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}