{"id":"W1496798136","doi":"10.1016/j.celrep.2015.04.061","title":"SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Italian Academy for Advanced Studies in America, Columbia University; Howard Hughes Medical Institute","keywords":"SUMO protein; Inhibitory postsynaptic potential; Constraint (computer-aided design); Cell biology; Chemistry; Biology; Neuroscience; Ubiquitin; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002961431,0.00007243088,0.00006978519,0.00001434869,0.00005479355,0.00001816696,0.00003551595,0.00007569642,0.000007234471],"category_scores_gemma":[0.00004435427,0.00005667847,0.00003420647,0.00002683836,0.00009072109,0.000009507339,0.00004891798,0.00003595025,2.813925e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009811522,"about_ca_system_score_gemma":0.0001089802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002391025,"about_ca_topic_score_gemma":0.000006365774,"domain_scores_codex":[0.9994389,0.00004651249,0.0001257488,0.000194962,0.0001149803,0.00007890096],"domain_scores_gemma":[0.9993619,0.000006925615,0.0002070103,0.0002753554,0.00007239141,0.00007644972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006615555,0.00006134162,0.02058064,0.00003835531,0.00001782171,0.00001297112,0.0003812169,0.00006406306,0.8973941,0.00001004163,0.001040176,0.08033318],"study_design_scores_gemma":[0.0001378404,0.00008014291,0.004712395,0.00001417138,0.00001491139,0.00004218723,0.0001235515,0.000113258,0.9893035,0.0005665597,0.004808239,0.00008325507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960223,0.003117795,0.0002710847,0.0001127282,0.000108784,0.0001685732,0.000002887186,0.000006244823,0.0001896164],"genre_scores_gemma":[0.999263,0.0003440305,0.0001371037,0.00005220961,0.00006486678,0.000005787047,0.00002913205,0.000007125917,0.00009672533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09190945,"threshold_uncertainty_score":0.2311281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02227916137900066,"score_gpt":0.2478949722745089,"score_spread":0.2256158108955082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}