{"id":"W1497676266","doi":"10.1186/ar1384","title":"Endothelin-1 induces extracellular matrix degradation via matrix metalloproteinases induction in human osteosarcoma cells","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Matrix metalloproteinase; Proinflammatory cytokine; Chondrosarcoma; Autocrine signalling; Extracellular matrix; Cancer research; Chemistry; Cytokine; Western blot; Receptor; Molecular biology; Biology; Inflammation; Medicine; Biochemistry; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004998701,0.0002218194,0.0003335343,0.0004442946,0.0002553056,0.0005157615,0.0001978491,0.0002862342,0.003963829],"category_scores_gemma":[0.000278793,0.0001610149,0.000603441,0.0005479081,0.0002622863,0.0002940746,0.0003485242,0.0007160532,0.0007206072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407459,"about_ca_system_score_gemma":0.0002926521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008729617,"about_ca_topic_score_gemma":0.0009418816,"domain_scores_codex":[0.9995152,0.00008645075,0.00006644447,0.00006437789,0.0001565648,0.0001109486],"domain_scores_gemma":[0.9998057,0.00006356223,0.00003084719,0.0000278,0.00004369177,0.00002824293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006004771,0.0004914281,0.003639805,0.0006502676,0.00004790213,0.000695735,0.0004726119,0.0002435094,0.9821414,0.0006365097,0.001232683,0.009147712],"study_design_scores_gemma":[0.0003092509,0.004231736,0.08016403,0.000115579,0.0001507982,0.002442809,0.001074563,0.004287785,0.8792914,0.0009363554,0.02694698,0.00004866301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738659,0.01384212,0.004943137,0.0005835465,0.0003994144,0.0001188575,0.001789981,0.0001042872,0.004352854],"genre_scores_gemma":[0.98133,0.005897752,0.002922141,0.0002813768,0.000122577,0.0001723796,0.00241886,0.00001003215,0.006844804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003963829,"threshold_uncertainty_score":0.0132603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05271745753299851,"score_gpt":0.3730802220920411,"score_spread":0.3203627645590426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}