{"id":"W1497676266","doi":"10.1186/ar1384","title":"Endothelin-1 induces extracellular matrix degradation via matrix metalloproteinases induction in human osteosarcoma cells","year":2004,"lang":"en","type":"article","venue":"Arthritis Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Canadian Arthritis Network; School of Medicine, University of California, San Diego; Menzies Institute for Medical Research; National Cancer Institute; Arthritis Society; University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Biogen; Lupus Research Institute; Pfizer; Natural Sciences and Engineering Research Council of Canada; Dutch Arthritis Association; Oesterreichische Nationalbank; Deutsche Forschungsgemeinschaft; Nuffield Foundation; Physiotherapy Foundation of Canada; Canadian Institutes of Health Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Lupus Research Alliance; Wellcome Trust; Newcastle University; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Austrian Science Fund; Arthritis Foundation","keywords":"Matrix metalloproteinase; Proinflammatory cytokine; Chondrosarcoma; Autocrine signalling; Extracellular matrix; Cancer research; Chemistry; Cytokine; Western blot; Receptor; Molecular biology; Biology; Inflammation; Medicine; Biochemistry; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0024997,0.0002833302,0.0004804434,0.001246863,0.0003978944,0.0001620303,0.0003664526,0.00030572,0.0009772839],"category_scores_gemma":[0.0004022743,0.000286157,0.0001615497,0.001512493,0.0004054905,0.0003743597,0.0002656036,0.001631464,0.000970701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005503407,"about_ca_system_score_gemma":0.0003652857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003131506,"about_ca_topic_score_gemma":0.000826752,"domain_scores_codex":[0.9943895,0.0006416074,0.0007407921,0.0008077741,0.002286548,0.001133718],"domain_scores_gemma":[0.9980188,0.0001874807,0.00009015193,0.0007570941,0.0005332074,0.0004132489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001651409,0.0006163241,0.000532362,0.0001106567,0.00002462636,0.001422971,0.0002077194,0.00003667979,0.9522936,0.001203891,0.00005410715,0.04333186],"study_design_scores_gemma":[0.00429546,0.001176036,0.001928522,0.0003587477,0.000009462611,0.0003091887,0.0005834884,0.00004874378,0.9854278,0.002257284,0.003337215,0.0002680428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870861,0.008130342,0.0003539165,0.001393265,0.00008517453,0.002084499,0.00001435236,0.00009721281,0.0007551771],"genre_scores_gemma":[0.9872901,0.001466353,0.002973001,0.00001794673,0.0002175124,0.0002786743,0.0001028004,0.00008563089,0.007567983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04306382,"threshold_uncertainty_score":0.9999591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05271745753299851,"score_gpt":0.3730802220920411,"score_spread":0.3203627645590426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}