{"id":"W149770547","doi":"10.1161/circ.118.suppl_18.s_534","title":"Abstract 5356: Brca1 Is An Essential Regulator Of Cardiac Function","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Doxorubicin; Apoptosis; Downregulation and upregulation; Medicine; In vivo; DNA damage; Cardiac function curve; Cancer research; Regulator; Cell biology; Internal medicine; Heart failure; Biology; DNA; Chemotherapy; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001476013,0.000735943,0.0005034112,0.0001970439,0.0002741393,0.0005246381,0.0003267397,0.0004719956,0.013239],"category_scores_gemma":[0.0001915882,0.0001936296,0.0001853869,0.0001340988,0.0002447725,0.0002001378,0.0003444778,0.0006204137,0.005280289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004563768,"about_ca_system_score_gemma":0.0002451649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003987812,"about_ca_topic_score_gemma":0.0002151452,"domain_scores_codex":[0.9998834,0.00001283882,0.00001204898,0.00004326207,0.00003267851,0.00001575414],"domain_scores_gemma":[0.9998797,0.00001607728,0.00004752705,0.000007882923,0.00001423279,0.00003452036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007079018,0.00005790112,0.0005876143,0.0003266714,0.000017983,0.0003564809,0.00001951318,0.0001405134,0.9810392,0.0003737609,0.002539475,0.01383298],"study_design_scores_gemma":[0.0002306447,0.001157392,0.04326949,0.000194384,0.0001538815,0.005558923,0.0000701993,0.001633914,0.8233864,0.0006156845,0.1237033,0.0000257567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8730238,0.05629235,0.009587617,0.004770772,0.001572829,0.0001699444,0.01156256,0.001566431,0.04145379],"genre_scores_gemma":[0.9082725,0.0109693,0.003732608,0.000738379,0.000449796,0.0001252934,0.009121639,0.0001330685,0.06645738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.013239,"threshold_uncertainty_score":0.04428887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649454062207496,"score_gpt":0.261084662067986,"score_spread":0.2345901214459111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}