{"id":"W1498149942","doi":"10.1186/s12885-015-1529-x","title":"TOPGEAR: a randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG)","year":2015,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; Mount Sinai Hospital","funders":"National Health and Medical Research Council; Medical Research Council","keywords":"Medicine; Perioperative; Epirubicin; Chemoradiotherapy; Chemotherapy; Surgery; Cancer; Randomized controlled trial; Surgical oncology; Clinical endpoint; Chemotherapy regimen; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003154261,0.002958975,0.003202432,0.0006346125,0.0005150182,0.001522301,0.00159597,0.002562022,0.01060083],"category_scores_gemma":[0.003219288,0.0008213929,0.003069475,0.0004543763,0.001981545,0.001686065,0.0007053266,0.004319931,0.001472558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008293699,"about_ca_system_score_gemma":0.001687798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008131565,"about_ca_topic_score_gemma":0.001610502,"domain_scores_codex":[0.998584,0.0009345729,0.00005374789,0.0001539218,0.00008743793,0.0001861869],"domain_scores_gemma":[0.9984665,0.0005192738,0.0003534249,0.0001442871,0.00007407528,0.0004424986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9797264,0.006225124,0.0002653437,0.0006339469,0.0006551855,0.00003398777,0.0000392946,0.0004189966,0.001648103,0.000256814,0.001040432,0.009056352],"study_design_scores_gemma":[0.9632137,0.03540337,0.0002337897,0.00001680734,0.0002427158,0.00001649968,0.00001001302,0.0001941369,0.0001758377,0.0001305859,0.0003544511,0.000008123608],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636178,0.006402854,0.001503246,0.002321696,0.002018466,0.01689598,0.002221064,0.0003723712,0.004646564],"genre_scores_gemma":[0.9424763,0.004794941,0.005669823,0.004522365,0.001604626,0.02956754,0.002893872,0.00008179696,0.008388754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01060083,"threshold_uncertainty_score":0.03546333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06666730756198039,"score_gpt":0.3813577451423654,"score_spread":0.314690437580385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}