{"id":"W1498284104","doi":"10.1046/j.1471-4159.2003.01534.x","title":"Peptidase activities of the 20/26S proteasome and a novel protease in human brain","year":2003,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Centre for Movement Disorders","funders":"","keywords":"Proteasome; Protease; Lactacystin; Proteases; Biochemistry; Proteolysis; Ubiquitin; Biology; Enzyme; Chemistry; Proteasome inhibitor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749339,0.0004263149,0.0001975277,0.0006548183,0.0001409802,0.000303326,0.0001052338,0.0002415299,0.0005798325],"category_scores_gemma":[0.0001770366,0.0000991899,0.0001900536,0.0002799845,0.0001993893,0.0002209493,0.0001313452,0.000224386,0.0003379925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000234676,"about_ca_system_score_gemma":0.0002308014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003127619,"about_ca_topic_score_gemma":0.000409817,"domain_scores_codex":[0.9998618,0.00001756284,0.00002220168,0.00004526509,0.00003478302,0.00001831311],"domain_scores_gemma":[0.9998966,0.000007807126,0.00004118983,0.00000617565,0.00001856316,0.00002948835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006657383,0.00009729286,0.005266348,0.0002493901,0.0000549177,0.001504063,0.0000556878,0.00008171811,0.9718049,0.0003346428,0.0004173227,0.01946793],"study_design_scores_gemma":[0.0001097668,0.00167508,0.263465,0.0001032648,0.0002182042,0.03907134,0.0001546011,0.001117164,0.6641918,0.001485681,0.02836735,0.00004069558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9270394,0.06353636,0.005606341,0.0003360941,0.0001085151,0.0000521874,0.0006407573,0.0001064883,0.002573871],"genre_scores_gemma":[0.9704055,0.01837167,0.006860622,0.0001216095,0.00009858392,0.00003882601,0.001670604,0.000009200619,0.002423411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006548183,"threshold_uncertainty_score":0.001939714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283058661386873,"score_gpt":0.2453929121274884,"score_spread":0.2325623255136197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}