{"id":"W1499029984","doi":"10.1593/neo.111626","title":"Genome-wide DNA Methylation Profiling of Cell-Free Serum DNA in Esophageal Adenocarcinoma and Barrett Esophagus","year":2012,"lang":"en","type":"article","venue":"Neoplasia","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Environmental Health Sciences; National Cancer Institute","keywords":"dNaM; DNA methylation; Biology; Genome; Adenocarcinoma; CpG site; DNA; Methylation; Molecular biology; Gene; Genetics; Cancer; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003901229,0.0001660355,0.0001865077,0.00009614639,0.0000452604,0.00001309755,0.0001399504,0.0002095582,0.00001509608],"category_scores_gemma":[0.0001146954,0.0001734638,0.00005316342,0.0001250323,0.00004861622,0.00001266873,0.0001276036,0.0001020151,0.000003915748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001770111,"about_ca_system_score_gemma":0.00004540743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001119907,"about_ca_topic_score_gemma":0.00002148834,"domain_scores_codex":[0.998857,0.00009504086,0.0003166793,0.0002735225,0.0001497523,0.0003080311],"domain_scores_gemma":[0.9993172,0.00003762317,0.0001330225,0.0003467969,0.00005227997,0.0001130518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002616439,0.00003457523,0.5454861,0.00003700819,0.000008935068,0.000001246984,0.0001486334,0.00003878444,0.453703,0.00003524879,0.000005377676,0.0004749978],"study_design_scores_gemma":[0.0003990136,0.00007775509,0.4724199,0.000003703736,0.00001151916,0.000001520979,0.0000378792,0.0000383745,0.5267646,0.0001042005,0.00005416691,0.00008735144],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.962595,0.03591054,0.0005513464,0.00003685441,0.0001391162,0.0002355061,0.00002012739,0.000007570269,0.0005038701],"genre_scores_gemma":[0.9965388,0.0002211256,0.002789278,0.00003112267,0.0001929605,0.00001398961,0.00008581061,0.00002660526,0.0001003571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07306613,"threshold_uncertainty_score":0.7073649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00925608203368222,"score_gpt":0.2315328009023324,"score_spread":0.2222767188686501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}