{"id":"W1499075266","doi":"10.1002/ijc.28180","title":"Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53‐mediated cellular senescence","year":2013,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia; Canada's Michael Smith Genome Sciences Centre; University of British Columbia Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cancer research; Biology; Colorectal adenoma; Carcinogenesis; Nucleophosmin; Colorectal cancer; Senescence; Downregulation and upregulation; Cell cycle; NPM1; Gene expression profiling; Cell; Pathology; Gene expression; Cancer; Medicine; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002033245,0.00009071059,0.0002171721,0.0001936988,0.00001582371,0.00001815676,0.0002791145,0.0000719283,0.0003792855],"category_scores_gemma":[0.0001868122,0.00006140511,0.00006420545,0.0002356742,0.0001702786,0.0001513258,0.00008577056,0.000343971,0.000004810279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000816219,"about_ca_system_score_gemma":0.000902079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968249,"about_ca_topic_score_gemma":0.0001755521,"domain_scores_codex":[0.9985766,0.00004970832,0.0004459097,0.0001042695,0.0006738746,0.0001496176],"domain_scores_gemma":[0.9984614,0.00008592894,0.0003197375,0.0000863816,0.0009461619,0.0001003724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005656191,0.00006645695,0.2008991,0.00004115027,0.0003097013,0.0001091808,0.0009277064,0.0002040214,0.7882222,0.00006437115,0.003027326,0.005563121],"study_design_scores_gemma":[0.005387746,0.0001750163,0.7665641,0.001232952,0.00005872541,0.0002168569,0.0003194188,0.002711621,0.2202805,0.0002795513,0.002647504,0.00012593],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900608,0.001806883,0.00001812372,0.007264015,0.0003502548,0.0002142364,0.0000105765,0.000003094157,0.0002720029],"genre_scores_gemma":[0.9982443,0.0006875293,0.00008927628,0.00046998,0.000182977,0.000008702694,0.000001327523,0.00001270031,0.0003032177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5679417,"threshold_uncertainty_score":0.4152911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008733848418216833,"score_gpt":0.2835667566929589,"score_spread":0.274832908274742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}