{"id":"W1499274698","doi":"10.1007/978-1-4615-0298-2_5","title":"Regulation of cytosolic phospholipase A2, cyclooxygenase-1 and -2 expression by PMA, TNFα, LPS and M-CSF in human monocytes and macrophages","year":2003,"lang":"en","type":"article","venue":"","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"U937 cell; Phospholipase A2; Tumor necrosis factor alpha; Lipopolysaccharide; Phorbol; Arachidonic acid; Prostaglandin E2; Eicosanoid; Monocyte; Macrophage; Cyclooxygenase; Cytosol; Chemistry; Biology; Cell culture; Internal medicine; Endocrinology; Protein kinase C; Cell biology; Biochemistry; Signal transduction; Enzyme; Immunology; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002694101,0.0002783216,0.0003286263,0.0003490136,0.0003166512,0.0004984743,0.0001150346,0.0002698136,0.0010901],"category_scores_gemma":[0.000249431,0.0002206005,0.0003573292,0.0003349642,0.0002739906,0.0003583526,0.0002206501,0.0004380567,0.0003046031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003188669,"about_ca_system_score_gemma":0.0003035812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186605,"about_ca_topic_score_gemma":0.001356166,"domain_scores_codex":[0.999772,0.0000458135,0.0000293904,0.00002409043,0.00003018959,0.00009849948],"domain_scores_gemma":[0.9998684,0.0000369831,0.00001887997,0.00001969757,0.00002852582,0.00002762351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004283768,0.00008771327,0.001551487,0.0001237274,0.0000108872,0.0003752119,0.0001905213,0.00007062803,0.990896,0.0001875465,0.0001043115,0.00211818],"study_design_scores_gemma":[0.000385058,0.001446706,0.06729056,0.00004024645,0.00007505213,0.0009407746,0.0006579582,0.001222252,0.9238036,0.0003194079,0.003798458,0.00001976699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947877,0.002762907,0.0007157342,0.000135899,0.0000511271,0.00003100882,0.0005533327,0.00001415391,0.0009482602],"genre_scores_gemma":[0.9938304,0.00159445,0.0007819608,0.00007947707,0.00005368552,0.0000915272,0.0006848539,0.000005178204,0.002878526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001186605,"threshold_uncertainty_score":0.003646791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006398965021800746,"score_gpt":0.2426167369656094,"score_spread":0.2362177719438087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}