{"id":"W1499370228","doi":"10.4049/jimmunol.0902324","title":"Lysine Acetylation Regulates Bruton’s Tyrosine Kinase in B Cell Activation","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RIKEN; Science and Technology Commission of Shanghai Municipality; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Genetics; National Natural Science Foundation of China","keywords":"Bruton's tyrosine kinase; Acetylation; Histone; Phosphorylation; Lysine; Histone acetyltransferase; Histone H3; Tyrosine phosphorylation; breakpoint cluster region; Molecular biology; Signal transduction; Tyrosine kinase; Biology; Cancer research; Cell biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009554438,0.0001753006,0.00009891928,0.0001916547,0.0001976958,0.0002582294,0.0001084701,0.0001979782,0.001443988],"category_scores_gemma":[0.0001115459,0.0001141202,0.0001540552,0.0001169053,0.0002062321,0.000170451,0.0002115803,0.0002659208,0.0005808904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003456168,"about_ca_system_score_gemma":0.00012689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006006612,"about_ca_topic_score_gemma":0.0008475524,"domain_scores_codex":[0.9999118,0.00001464205,0.000003997495,0.00001613183,0.00001764848,0.00003568206],"domain_scores_gemma":[0.9999399,0.000008319804,0.00001514748,0.000005156857,0.00000713402,0.00002426082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001831836,0.00001910458,0.0007827272,0.00001876524,0.000002814659,0.00008160701,0.00001261874,0.00004115294,0.9970565,0.0001601829,0.00005147184,0.001589792],"study_design_scores_gemma":[0.00005380361,0.0002244534,0.09170914,0.000008836095,0.00001767183,0.0006500873,0.00005935094,0.001307504,0.9013591,0.0003977733,0.004202921,0.00000931453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99504,0.002097036,0.000931011,0.0000958911,0.0000238058,0.000009038586,0.0000683901,0.00003035371,0.001704553],"genre_scores_gemma":[0.9978868,0.0006082099,0.0002814675,0.00001985658,0.00001062756,0.000003625835,0.00009125407,0.000005028148,0.001093064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443988,"threshold_uncertainty_score":0.004830599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430214965660052,"score_gpt":0.2822660243852541,"score_spread":0.2679638747286536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}