{"id":"W1499397365","doi":"10.1111/j.1538-7836.2004.00732.x","title":"A novel type 2A (Group II) von Willebrand disease mutation (L1503Q) associated with loss of the highest molecular weight von Willebrand factor multimers","year":2004,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Von Willebrand disease; Von Willebrand factor; ADAMTS13; Chemistry; Mutant; Proteolysis; Molecular biology; Transversion; Recombinant DNA; Mutant protein; Platelet; Mutation; Protease; Protein subunit; Biochemistry; Gene; Biology; Enzyme; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002608725,0.00165648,0.0005761923,0.001100337,0.0007578658,0.0005234855,0.0009445889,0.003867412,0.002542489],"category_scores_gemma":[0.001795788,0.0002959563,0.0008044633,0.0006693001,0.0009559277,0.0005137319,0.0004606685,0.001041798,0.0007297975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000466719,"about_ca_system_score_gemma":0.0003950384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00193088,"about_ca_topic_score_gemma":0.001387576,"domain_scores_codex":[0.9997124,0.0000394729,0.00004238562,0.00008513463,0.00006087409,0.00005958037],"domain_scores_gemma":[0.9991748,0.0003110626,0.0001880023,0.00004113004,0.00006258831,0.0002224848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0004685812,0.0001699397,0.009502064,0.00006837614,0.00006601016,0.9154279,0.0004465853,0.0002732876,0.06602492,0.001388682,0.001604181,0.004559403],"study_design_scores_gemma":[0.0002406752,0.0005550719,0.02833484,0.00002904092,0.0001213885,0.9470315,0.0001320428,0.001406803,0.01718333,0.001064255,0.003845606,0.00005538248],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896486,0.0006958874,0.002663369,0.001516681,0.0003235659,0.0001317262,0.0005178224,0.0001601957,0.004342139],"genre_scores_gemma":[0.9968112,0.0001103607,0.001222797,0.0003512921,0.0001638067,0.00002045751,0.0001422012,0.00002639249,0.001151511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003867412,"threshold_uncertainty_score":0.008505523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02396535416107279,"score_gpt":0.2635833908441456,"score_spread":0.2396180366830728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}