{"id":"W1499863817","doi":"10.5772/30294","title":"A Multi-Targeted Antisense Oligonucleotide-Based Therapy Directed at Phosphodiesterases 4 and 7 for COPD","year":2012,"lang":"en","type":"book-chapter","venue":"InTech eBooks","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pharmaxis (Canada)","funders":"","keywords":"Oligonucleotide; Phosphodiesterase; Antisense therapy; COPD; Computational biology; Medicine; Pharmacology; Biology; Internal medicine; Biochemistry; Locked nucleic acid; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001117168,0.0004648724,0.0003655411,0.00009285274,0.0001780527,0.00003654818,0.0001064134,0.0005594701,0.00008040651],"category_scores_gemma":[0.00003493047,0.000418111,0.0002263823,0.000008774347,0.0002330306,0.000003189906,0.00009279166,0.0001349097,0.00001398707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004693539,"about_ca_system_score_gemma":0.00006760065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001238387,"about_ca_topic_score_gemma":0.00007587314,"domain_scores_codex":[0.9986867,0.00002431678,0.0003325083,0.0005303495,0.0001250895,0.0003010595],"domain_scores_gemma":[0.998954,0.00004680355,0.0002404846,0.0004138737,0.0002026104,0.000142214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001085992,0.00004021177,0.0001236027,0.00006508441,0.0002252561,0.000004599222,0.00005858334,7.671212e-7,0.9719931,0.00005895537,0.002166025,0.02417779],"study_design_scores_gemma":[0.001288214,0.0002105516,0.0001451174,0.00007861008,0.00004346924,0.0000154861,0.000003102291,0.00003700813,0.5788866,0.00005141551,0.4188893,0.000351124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6444466,0.1632118,0.03673459,0.0007577709,0.009479388,0.01810787,0.004971077,0.002334623,0.1199563],"genre_scores_gemma":[0.5505778,0.001124545,0.003955991,0.001423242,0.000519062,0.0002127545,0.001653089,0.0002708918,0.4402627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4167233,"threshold_uncertainty_score":0.9998271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02796489405239429,"score_gpt":0.2587145121987917,"score_spread":0.2307496181463974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}