{"id":"W1500219196","doi":"10.1016/j.neuropharm.2015.08.024","title":"Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine","year":2015,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; National Institutes of Health","keywords":"mTORC1; mTORC2; PI3K/AKT/mTOR pathway; P70-S6 Kinase 1; Dopamine; Phosphorylation; Nucleus accumbens; Chemistry; Pharmacology; Signal transduction; Cell biology; Biology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002145158,0.0003406032,0.0004228016,0.0003125771,0.0003915318,0.0004823,0.0003543304,0.0003225595,0.002156528],"category_scores_gemma":[0.0002191309,0.0002338253,0.0003552333,0.0001175359,0.0005548503,0.0004059705,0.000445525,0.0006685548,0.0004941066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006640624,"about_ca_system_score_gemma":0.0004935128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009499916,"about_ca_topic_score_gemma":0.002055622,"domain_scores_codex":[0.9998287,0.00004003414,0.00001750385,0.00003425379,0.00002344565,0.00005596438],"domain_scores_gemma":[0.9998932,0.00001460484,0.00003060885,0.00001601589,0.0000102084,0.00003532939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002561248,0.0001006303,0.0007366512,0.0001487359,0.00003814153,0.0003716868,0.00005716987,0.0002511648,0.9887221,0.002101959,0.0004029577,0.004507574],"study_design_scores_gemma":[0.0002962548,0.0006880159,0.0894181,0.00007305918,0.0001525162,0.001590667,0.0003201413,0.005309993,0.8880892,0.001938263,0.01206765,0.0000562044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840703,0.008906473,0.001645381,0.0007672517,0.0001099398,0.00002567448,0.0006724783,0.00008193611,0.003720606],"genre_scores_gemma":[0.9952469,0.00200759,0.0008076809,0.00009068282,0.0000234533,0.00002030792,0.0003194298,0.00002374329,0.001460135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002156528,"threshold_uncertainty_score":0.007214308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05874840391659025,"score_gpt":0.3322670156506222,"score_spread":0.2735186117340319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}