{"id":"W1500225421","doi":"10.4049/jimmunol.171.1.368","title":"Vulnerability of Human Neurons to T Cell-Mediated Cytotoxicity","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":213,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Montreal Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Cytotoxic T cell; CD8; Biology; Cytotoxicity; Cell biology; T cell; Programmed cell death; Neuron; Major histocompatibility complex; Neuroscience; Immunology; Apoptosis; Antigen; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007775693,0.0001056376,0.0002193212,0.0001456845,0.0001779546,0.00001093211,0.0004194491,0.00004526547,0.0002098377],"category_scores_gemma":[0.001713938,0.00007336161,0.00007603571,0.0002944382,0.0001303497,0.00009342526,0.00004706,0.0003535463,0.00004112768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001840428,"about_ca_system_score_gemma":0.00006495514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002042273,"about_ca_topic_score_gemma":0.000001904988,"domain_scores_codex":[0.9973734,0.001526389,0.0005818372,0.0001188862,0.000223167,0.0001763138],"domain_scores_gemma":[0.9984902,0.0005292274,0.0004671713,0.0003288086,0.0001231983,0.00006137133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006315603,0.00009264942,0.00002179889,0.000002868492,0.000002525495,0.00000716387,0.0002225667,0.0002371622,0.9949821,0.004117172,0.0002232083,0.00002759955],"study_design_scores_gemma":[0.0004282718,0.0007259223,0.0007799278,0.000003056539,0.000009646667,0.0001890564,0.00004213819,0.00001665281,0.9964245,0.0006851023,0.0006376153,0.00005810417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968843,0.00002132559,0.0009178001,0.0007333437,0.0004184812,0.0001537948,0.000003622932,0.00001460891,0.000852686],"genre_scores_gemma":[0.9986026,0.00004253891,0.00008184478,0.001047143,0.00002181817,0.000001398757,1.474522e-7,0.00001120252,0.000191266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00343207,"threshold_uncertainty_score":0.29916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03531769226267945,"score_gpt":0.2783114618214199,"score_spread":0.2429937695587405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}