{"id":"W1500239426","doi":"10.4049/jimmunol.172.3.1670","title":"The C4A and C4B Isotypic Forms of Human Complement Fragment C4b Have the Same Intrinsic Affinity for Complement Receptor 1 (CR1/CD35)","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Surface plasmon resonance; Chemistry; Isotype; Monomer; Binding site; C4A; Stereochemistry; Biophysics; Biochemistry; Biology; Antibody; Materials science; Polymer; Nanotechnology; Monoclonal antibody; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002199083,0.0002919322,0.000620085,0.0001189701,0.001240027,0.00002967288,0.001164401,0.0001074376,0.0004120683],"category_scores_gemma":[0.0001618828,0.0001410281,0.0002523238,0.00009836329,0.001072673,0.00007987314,0.0004850603,0.0004814712,0.00002522344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002055046,"about_ca_system_score_gemma":0.0001466978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001928001,"about_ca_topic_score_gemma":0.0005246777,"domain_scores_codex":[0.9970013,0.0007195424,0.001388909,0.0001806277,0.0001343627,0.0005752761],"domain_scores_gemma":[0.9962299,0.001326611,0.00140271,0.0006633795,0.0003457577,0.00003156838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009187964,0.002117417,0.00828082,0.0002541631,0.01104235,0.000006814872,0.01499036,0.0002580292,0.7192156,0.1716071,0.03960822,0.02343108],"study_design_scores_gemma":[0.04087216,0.01971575,0.1655185,0.0009542246,0.002190766,0.001362236,0.07733088,0.000008056836,0.2170046,0.08613582,0.3876206,0.001286454],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756795,0.01321417,0.0004939619,0.007906438,0.001047101,0.001407031,0.0001338688,0.00001593015,0.0001020397],"genre_scores_gemma":[0.9984202,0.0008384475,0.0001105982,0.0002847875,0.00009136843,0.00005877196,0.00003888836,0.00002232031,0.0001345825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5022111,"threshold_uncertainty_score":0.953741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02951342554490428,"score_gpt":0.2878203420349901,"score_spread":0.2583069164900859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}