{"id":"W1500502973","doi":"10.4049/jimmunol.180.4.2174","title":"Induction of Broad Cross-Subtype-Specific HIV-1 Immune Responses by a Novel Multivalent HIV-1 Peptide Vaccine in Cynomolgus Macaques","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; Variation Biotechnologies (Canada); Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Immunogenicity; HIV vaccine; Immune system; Heterologous; Virology; Biology; AIDS Vaccines; Immunology; Immunity; Human immunodeficiency virus (HIV); Antigen; Macaque; Potency; HIV Antigens; Simian immunodeficiency virus; Peptide vaccine; Antigenic variation; Vaccine trial; Epitope; Genetics; Viral disease; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002461087,0.0003355703,0.000339103,0.0002797972,0.0001792957,0.0003048728,0.0001927853,0.0003045611,0.0004981445],"category_scores_gemma":[0.0002009543,0.0001122689,0.0002065794,0.00007057349,0.0002588663,0.0001817018,0.0003042862,0.0005447761,0.0001162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002712948,"about_ca_system_score_gemma":0.0001939616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007001404,"about_ca_topic_score_gemma":0.0007905512,"domain_scores_codex":[0.9998939,0.0000180285,0.000006414389,0.00002699454,0.0000154138,0.00003921649],"domain_scores_gemma":[0.9999224,0.000011644,0.00001656175,0.0000101182,0.00001175244,0.00002751657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002803401,0.000099357,0.0004223681,0.00003654317,0.000008726633,0.00006003969,0.00004152419,0.0002080501,0.9956741,0.00008645328,0.00003440015,0.003048004],"study_design_scores_gemma":[0.000434377,0.01180379,0.01997839,0.00006093462,0.0001707326,0.001567115,0.0001983334,0.006310659,0.9523988,0.0006856688,0.006362384,0.00002872093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982458,0.000378376,0.001031859,0.00003747725,0.00000884948,0.00003157214,0.00003490713,0.00002027885,0.0002109631],"genre_scores_gemma":[0.997317,0.0003084599,0.001644646,0.00006417056,0.00001283749,0.00004803073,0.0001127795,0.000008556212,0.000483473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007001404,"threshold_uncertainty_score":0.001968384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02752525288724068,"score_gpt":0.2828730990176073,"score_spread":0.2553478461303666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}