{"id":"W1500542869","doi":"10.1002/j.1939-4640.2002.tb02314.x","title":"Activation of Protein Kinase A During Human Sperm Capacitation and Acrosome Reaction","year":2002,"lang":"en","type":"article","venue":"Journal of Andrology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Capacitation; Acrosome reaction; Second messenger system; Phosphodiesterase; Adenylyl cyclase; Protein kinase A; Cyclic adenosine monophosphate; Tyrosine phosphorylation; Adenylate kinase; Endocrinology; Intracellular; Sperm; Cell biology; Chemistry; Phosphorylation; Signal transduction; Internal medicine; Biology; Biochemistry; Enzyme; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001653433,0.0002085826,0.0002311287,0.0002671413,0.0001709145,0.0002846935,0.0001080871,0.0002337187,0.001896402],"category_scores_gemma":[0.0002090289,0.0001101172,0.0001797441,0.0002275904,0.0001752048,0.0001830064,0.0001229864,0.0002343578,0.0003687432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829679,"about_ca_system_score_gemma":0.0002365958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009360678,"about_ca_topic_score_gemma":0.0008069855,"domain_scores_codex":[0.9998723,0.00002347294,0.000009059192,0.00003194254,0.00002911903,0.00003408941],"domain_scores_gemma":[0.9999311,0.00001480312,0.00002002155,0.000005984893,0.00001288115,0.00001521914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001607723,0.00005055241,0.00265194,0.0001779445,0.00002525446,0.0002546762,0.00009983895,0.00006285574,0.9905823,0.0001165526,0.0001209353,0.004249379],"study_design_scores_gemma":[0.00006192291,0.0009542828,0.1324929,0.00002265607,0.00005347301,0.001127214,0.0001612795,0.0008417486,0.8594623,0.000150379,0.004654031,0.00001785265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983498,0.01258564,0.001421842,0.0001150637,0.00004028921,0.00006334516,0.0004187279,0.00005451463,0.001802445],"genre_scores_gemma":[0.9960853,0.001651721,0.0004952424,0.00004332951,0.00001686309,0.00003213132,0.0003149886,0.000006525172,0.001353957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001896402,"threshold_uncertainty_score":0.00634414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02930848172277538,"score_gpt":0.2775220201450829,"score_spread":0.2482135384223076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}