{"id":"W1500682602","doi":"10.1371/journal.pone.0131129","title":"Widely Used Herpes Simplex Virus 1 ICP0 Deletion Mutant Strain dl1403 and Its Derivative Viruses Do Not Express Glycoprotein C Due to a Secondary Mutation in the gC Gene","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Herpes simplex virus; Biology; Mutant; Gene; Virus; Mutation; Molecular biology; Virology; Frameshift mutation; Herpesvirus glycoprotein B; Viral replication; Genetics; Viral entry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002712764,0.0007175201,0.000468094,0.0005902045,0.000281275,0.0004173128,0.0006817484,0.0003623093,0.002110284],"category_scores_gemma":[0.0002626086,0.0001835908,0.0003370828,0.0005352583,0.000309338,0.0002429461,0.0004786952,0.0009757575,0.001057542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005215296,"about_ca_system_score_gemma":0.0004169295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008489406,"about_ca_topic_score_gemma":0.0009616658,"domain_scores_codex":[0.999644,0.00004383268,0.00004548759,0.00007038446,0.0001571852,0.00003899437],"domain_scores_gemma":[0.9998298,0.00002635317,0.00004474825,0.00004437974,0.00002141752,0.00003335352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001414892,0.00004632588,0.0003628323,0.00006217257,0.000008190755,0.00005337764,0.00002819222,0.00004862978,0.9948719,0.0003338843,0.0002192747,0.003823655],"study_design_scores_gemma":[0.00001753327,0.0002351384,0.002137529,0.000009951361,0.00002621722,0.0009213657,0.0000339926,0.0003531769,0.9829149,0.0001203466,0.01321764,0.00001207925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526038,0.003075736,0.02629219,0.0002171819,0.000252844,0.0004978497,0.006424448,0.0009719415,0.009664025],"genre_scores_gemma":[0.9073212,0.003005603,0.05076275,0.0001654834,0.00003098785,0.000662286,0.01783578,0.0004553601,0.01976069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002110284,"threshold_uncertainty_score":0.007059574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1078318012363326,"score_gpt":0.3031976426907912,"score_spread":0.1953658414544586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}