{"id":"W1500856445","doi":"10.1093/nar/gkv546","title":"The Cas6e ribonuclease is not required for interference and adaptation by the<i>E. coli</i>type I-E CRISPR-Cas system","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Agence Nationale de la Recherche","keywords":"Trans-activating crRNA; CRISPR; Biology; CRISPR interference; RNA; Genetics; DNA; Cas9; Transcription (linguistics); Nuclease; Endoribonuclease; Computational biology; Gene; RNase P","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000249574,0.0004660721,0.0005476598,0.0002694781,0.0002724324,0.0007363478,0.0006163821,0.0006427005,0.003044824],"category_scores_gemma":[0.0006490431,0.0002788194,0.0005675163,0.0002050398,0.0003878326,0.0004016455,0.0004470997,0.00101435,0.001856116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003818015,"about_ca_system_score_gemma":0.0005777949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049891,"about_ca_topic_score_gemma":0.001160146,"domain_scores_codex":[0.9992827,0.0001099529,0.0001067428,0.0001502247,0.0002371801,0.000113333],"domain_scores_gemma":[0.9993925,0.0001086949,0.0001301242,0.0001367714,0.00008379744,0.0001481463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008792907,0.00003752342,0.0003378144,0.00003376446,0.000006228024,0.0001111069,0.000009819068,0.00005638253,0.9974862,0.0003510759,0.0001741199,0.001308079],"study_design_scores_gemma":[0.00001123927,0.00005105616,0.003294239,0.000006807638,0.000007658187,0.0006160209,0.0000161103,0.001184703,0.9884415,0.0000938754,0.006266585,0.00001028182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9502953,0.002025012,0.03446733,0.0005989436,0.0002521144,0.0001005425,0.002401378,0.0008014461,0.009057806],"genre_scores_gemma":[0.9740283,0.0004719222,0.01154173,0.0002879394,0.000021809,0.00006842982,0.004234499,0.0002430835,0.009102219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003044824,"threshold_uncertainty_score":0.0101859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07560576551895158,"score_gpt":0.3810102089663627,"score_spread":0.3054044434474111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}