{"id":"W1500856445","doi":"10.1093/nar/gkv546","title":"The Cas6e ribonuclease is not required for interference and adaptation by the<i>E. coli</i>type I-E CRISPR-Cas system","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Agence Nationale de la Recherche","keywords":"Trans-activating crRNA; CRISPR; Biology; CRISPR interference; RNA; Genetics; DNA; Cas9; Transcription (linguistics); Nuclease; Endoribonuclease; Computational biology; Gene; RNase P","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001137106,0.0001094662,0.00009213437,0.0000277711,0.0003309532,0.0001214794,0.0003068541,0.0001060719,0.00000284281],"category_scores_gemma":[0.0004315868,0.00007372293,0.00003569235,0.000126602,0.0001882088,0.000005416121,0.0001777204,0.0001475925,0.00001521305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004102706,"about_ca_system_score_gemma":0.00009741433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009232795,"about_ca_topic_score_gemma":0.00004136288,"domain_scores_codex":[0.9988068,0.0001103912,0.0001793212,0.0002821089,0.0002754628,0.000345915],"domain_scores_gemma":[0.9988884,0.00009550693,0.00003136361,0.0004015596,0.0004380959,0.0001450733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001450836,0.00004589615,0.000297457,0.0001521653,0.0001074197,0.000004462607,0.002464946,0.00009125959,0.6737342,0.001138919,0.2877479,0.03276447],"study_design_scores_gemma":[0.001585156,0.001638749,0.0004618932,0.00006375541,0.00003209757,0.00005207309,0.01074852,0.04031954,0.4140468,0.0001876593,0.5305176,0.0003462222],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659173,0.004732681,0.02343233,0.003066265,0.0003952269,0.001033807,0.0001018961,0.00003380143,0.001286644],"genre_scores_gemma":[0.9977566,0.0002278339,0.0003152766,0.0001131043,0.0001597004,0.00006813245,0.00002426277,0.00002620823,0.001308876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2596875,"threshold_uncertainty_score":0.3006334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07560576551895158,"score_gpt":0.3810102089663627,"score_spread":0.3054044434474111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}