{"id":"W1501230743","doi":"10.4049/jimmunol.188.supp.108.7","title":"Bacterial DNA-induced anti-apoptotic c-IAP-2 protects human monocytic cells against HIV-Vpr-mediated mitochondrial membrane depolarization and apoptosis through TRAF 1/2 via sequential inhibition of pro-apoptotic Caspase 8, Bid and Bax (108.7)","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agricultural Research Institute of Ontario; University of Ottawa","funders":"","keywords":"Apoptosis; Depolarization; Biology; Cell biology; Caspase-9; Downregulation and upregulation; Inhibitor of apoptosis domain; Caspase; DNA damage; Mitochondrion; Programmed cell death; Molecular biology; DNA; Biochemistry; Gene; Biophysics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009920522,0.000386348,0.00024703,0.0001719879,0.0001359553,0.0002499131,0.0001425246,0.0002162661,0.001154216],"category_scores_gemma":[0.0001009693,0.0001328028,0.0002215695,0.0001217985,0.0001520381,0.0001161315,0.0001260662,0.0006464287,0.0003407869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000242377,"about_ca_system_score_gemma":0.000265178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004926444,"about_ca_topic_score_gemma":0.0008136407,"domain_scores_codex":[0.9998894,0.00001953517,0.00001368226,0.00001597702,0.00002707553,0.00003439008],"domain_scores_gemma":[0.9999481,0.000008042577,0.00001378611,0.000008651778,0.000007568802,0.00001383476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001902814,0.00004222905,0.00006969814,0.0000453323,0.000004052536,0.00003810375,0.000009381777,0.00003096431,0.9989742,0.00003043199,0.0000247514,0.0005405617],"study_design_scores_gemma":[0.00004954762,0.0006000791,0.002826117,0.000008866962,0.00001061004,0.0001878856,0.00001893116,0.0004728918,0.9946058,0.00002531352,0.001190787,0.000003198631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945709,0.002354718,0.001689642,0.00008499975,0.0000502147,0.0000453511,0.0004328198,0.00006046141,0.000710829],"genre_scores_gemma":[0.9937802,0.001032876,0.0023196,0.00006756779,0.00002055729,0.00005966921,0.0008892301,0.000008177321,0.001822061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001154216,"threshold_uncertainty_score":0.003861248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02139991198509809,"score_gpt":0.2519542985745202,"score_spread":0.2305543865894221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}