{"id":"W1501569859","doi":"10.1161/circ.130.suppl_2.15414","title":"Abstract 15414: Ablation of Aryl Hydrocarbon Nuclear Translocator (ARNT) in the Heart Leads to Diabetic Cardiomyopathy Phenotype Through PPARα Activity","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre","funders":"","keywords":"Aryl hydrocarbon receptor nuclear translocator; Diabetic cardiomyopathy; Gene knockdown; Transcription factor; Internal medicine; Endocrinology; Peroxisome proliferator-activated receptor; Medicine; Biology; Cardiomyopathy; Biochemistry; Aryl hydrocarbon receptor; Gene; Receptor; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002062832,0.0007909099,0.0005333666,0.0005392095,0.0003623072,0.0003326617,0.0004856983,0.0006128016,0.006322789],"category_scores_gemma":[0.000124408,0.0003288325,0.0005202819,0.0003674844,0.0005898448,0.0002563381,0.0003433509,0.001313748,0.002246931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003723177,"about_ca_system_score_gemma":0.0003793692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005052145,"about_ca_topic_score_gemma":0.0006423569,"domain_scores_codex":[0.9996845,0.00003988626,0.0000453285,0.00008519334,0.00009348353,0.00005171334],"domain_scores_gemma":[0.9997436,0.00002820449,0.00009532961,0.00002048589,0.00002003419,0.00009223956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003289345,0.00006679568,0.0001452225,0.00007489784,0.00000852394,0.0001680796,0.00001232791,0.00003599922,0.997739,0.0001192819,0.0001636362,0.001137259],"study_design_scores_gemma":[0.0002952717,0.0009058381,0.008005876,0.00003307443,0.00009653932,0.001823861,0.00007385293,0.0009863675,0.9759073,0.0001701603,0.01168549,0.00001636875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721859,0.003164607,0.01256882,0.001157901,0.0004765146,0.0001649834,0.004521834,0.0006425415,0.005116887],"genre_scores_gemma":[0.9365232,0.003856907,0.01158482,0.0006558418,0.0001856437,0.0004634156,0.007867216,0.0003882528,0.03847475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006322789,"threshold_uncertainty_score":0.0211519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139405552759513,"score_gpt":0.2398622405564849,"score_spread":0.2284681850288897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}