{"id":"W1502109765","doi":"10.1161/circ.129.suppl_1.mp57","title":"Abstract MP57: Pathway and Network Analysis of GWAS reveals Novel Candidate Causal Links between Key Biological Processes and Coronary Artery Disease","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Genome-wide association study; Computational biology; Coronary artery disease; Biological pathway; Biological network; Medicine; Genetic association; CAD; Bioinformatics; Genetics; Biology; Gene; Single-nucleotide polymorphism; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001356256,0.0007450432,0.0009392488,0.002563316,0.0004182766,0.001071908,0.0006623391,0.0003112553,0.006452699],"category_scores_gemma":[0.003145217,0.0002793046,0.001978583,0.003080519,0.0002876461,0.000435999,0.0007972745,0.0005989187,0.0004072456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004154266,"about_ca_system_score_gemma":0.0007734653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003279139,"about_ca_topic_score_gemma":0.003312229,"domain_scores_codex":[0.9992198,0.0002741142,0.00005699449,0.0002584542,0.000121801,0.00006886765],"domain_scores_gemma":[0.9983804,0.0008722743,0.0003072106,0.0001901896,0.0001401351,0.0001098922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004534304,0.0003196458,0.7451505,0.002353064,0.01452398,0.002159902,0.0003335092,0.02827689,0.08410237,0.003296237,0.008782663,0.1061668],"study_design_scores_gemma":[0.0006947488,0.0006933264,0.8660992,0.0001680125,0.008208198,0.001741366,0.0002660486,0.0936626,0.01136443,0.01018754,0.006795486,0.0001189621],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944088,0.003576437,0.03374389,0.000754624,0.00006632764,0.0001016522,0.01505696,0.001134713,0.001477498],"genre_scores_gemma":[0.9805422,0.0007593567,0.01236184,0.00009709602,0.00004795837,0.00009452523,0.005430957,0.00008762722,0.0005785377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006452699,"threshold_uncertainty_score":0.02158648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490076748247571,"score_gpt":0.2329319890751847,"score_spread":0.218031221592709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}