{"id":"W1502333420","doi":"10.1111/j.1538-7836.2008.02912.x","title":"Proteolytic cleavage of carboxypeptidase N markedly increases its antifibrinolytic activity","year":2008,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Plasmin; Antifibrinolytic; Carboxypeptidase; Chemistry; Proteolysis; Fibrinolysis; Lysis; Biochemistry; Cleavage (geology); Aprotinin; Plasminogen activator; Tissue plasminogen activator; Enzyme; Tranexamic acid; Biology; Medicine; Internal medicine; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002436558,0.000407681,0.0004024636,0.0001797592,0.0001119271,0.0002880789,0.0001757674,0.0003662684,0.001861492],"category_scores_gemma":[0.000382788,0.0001541195,0.000362541,0.0001399398,0.0002142313,0.0002216946,0.0001711795,0.0006135502,0.0005226267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000255731,"about_ca_system_score_gemma":0.0002416308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000403292,"about_ca_topic_score_gemma":0.000375442,"domain_scores_codex":[0.9998385,0.00003604392,0.00001677399,0.00002247173,0.00002856826,0.00005757885],"domain_scores_gemma":[0.9997666,0.00007734531,0.00004154219,0.00003711511,0.00002296011,0.00005426892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001140749,0.0000664361,0.0001852039,0.00003039521,0.00001031545,0.0001445166,0.000005338955,0.00004601776,0.9962757,0.00005294783,0.00007333558,0.001969098],"study_design_scores_gemma":[0.00004692216,0.0004855015,0.002583845,0.000003645566,0.00001317105,0.0005734242,0.00000769375,0.0002972472,0.9949531,0.0000344367,0.000997753,0.000003192231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991259,0.003675363,0.00251195,0.0001785595,0.00007986408,0.00002641735,0.0002312579,0.00005787821,0.00197968],"genre_scores_gemma":[0.9948776,0.001137199,0.001721273,0.00008017824,0.00003895546,0.00001744349,0.0006264571,0.0000119607,0.001488928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001861492,"threshold_uncertainty_score":0.006227255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08938994462584804,"score_gpt":0.3155324183511187,"score_spread":0.2261424737252706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}