{"id":"W1502618518","doi":"10.1371/journal.pone.0131507","title":"Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Science for Life Laboratory; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Inosine; Nucleotide; Hydrolase; Biochemistry; Inosine monophosphate; Enzyme; Stereochemistry; Adenosine monophosphate; Purine; Chemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006252345,0.00005636237,0.00007257016,0.000009268885,0.00004810965,0.00000992557,0.00005284977,0.0000406609,0.00001542155],"category_scores_gemma":[0.00006775192,0.00004293575,0.0000221944,0.00002720202,0.00003313174,0.00000367386,0.00002474414,0.00001454735,6.366781e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005335919,"about_ca_system_score_gemma":0.00001491011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000612028,"about_ca_topic_score_gemma":0.000003157931,"domain_scores_codex":[0.9996135,0.00001404857,0.000102482,0.0001121021,0.00009235337,0.0000655412],"domain_scores_gemma":[0.9996263,0.000008431169,0.00006021759,0.0001250948,0.0001221179,0.00005777443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001407237,0.00007795987,0.004372868,0.00002485115,0.00005312376,3.883972e-8,0.00002753074,0.00001910612,0.9930584,0.0003728245,0.001597503,0.0002551154],"study_design_scores_gemma":[0.0006547124,0.0001412113,0.03498339,0.000009215074,0.00004659739,2.237072e-7,0.00002832918,0.002273808,0.9611115,0.0002882422,0.0003875176,0.00007518453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976891,0.001529066,0.00007721504,0.0002978519,0.00001468327,0.000216647,0.00005603722,0.000004403724,0.0001149616],"genre_scores_gemma":[0.9985968,0.0000285949,0.0001673892,0.00005495051,0.00007542229,0.0000109952,0.000112367,0.000007012905,0.0009464945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03194679,"threshold_uncertainty_score":0.1750869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0503614956237217,"score_gpt":0.2552015389443242,"score_spread":0.2048400433206025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}