{"id":"W1502635587","doi":"10.1002/9781118775882.ch1","title":"Covalent and Noncovalent Bioconjugation Strategies","year":2014,"lang":"ca","type":"other","venue":"","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Bioconjugation; Biomolecule; Chemistry; Bioorthogonal chemistry; Covalent bond; Combinatorial chemistry; Nucleic acid; Biochemistry; Click chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001222989,0.0005343105,0.0004616789,0.00004896662,0.0001541877,0.0002295692,0.0002789195,0.0007245323,0.05171075],"category_scores_gemma":[0.00002565261,0.0005265336,0.0001372987,0.00009838751,0.0002801938,0.00005711138,0.0001321106,0.0003688081,0.00147667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007646768,"about_ca_system_score_gemma":0.000136159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007583994,"about_ca_topic_score_gemma":0.00003680618,"domain_scores_codex":[0.9980868,0.00002010559,0.0004844352,0.0008079593,0.0002588264,0.0003419173],"domain_scores_gemma":[0.9984307,0.0001273632,0.0003658864,0.0007955329,0.00006941373,0.0002111251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006383377,0.0007891249,0.0006588349,0.009561878,0.0007847649,0.00001305367,0.0004008275,0.0000295337,0.5206266,0.0590579,0.384868,0.02314567],"study_design_scores_gemma":[0.000632641,0.00002082064,0.00006374106,0.000407917,0.0001809209,0.00002445062,0.0006534723,0.0001986661,0.1230207,0.000867491,0.8732687,0.0006604497],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.01333677,0.0009290971,0.00130277,0.0007033781,0.00009971049,0.0002877685,0.0001629176,0.0001904978,0.9829871],"genre_scores_gemma":[0.237583,0.001359186,0.0004173245,0.0001534853,0.001229592,0.0001321449,0.0004593718,0.0001892909,0.7584766],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.4884007,"threshold_uncertainty_score":0.9997186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008544337441018094,"score_gpt":0.2526938636458835,"score_spread":0.2441495262048654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}