{"id":"W1502635587","doi":"10.1002/9781118775882.ch1","title":"Covalent and Noncovalent Bioconjugation Strategies","year":2014,"lang":"ca","type":"other","venue":"","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Bioconjugation; Biomolecule; Chemistry; Bioorthogonal chemistry; Covalent bond; Combinatorial chemistry; Nucleic acid; Biochemistry; Click chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003935602,0.001129766,0.0003783033,0.001023859,0.0004101322,0.0008461279,0.0009112612,0.000577138,0.006515421],"category_scores_gemma":[0.0002835647,0.0003548906,0.0004009177,0.001008412,0.0004344977,0.0006566481,0.0008177913,0.0009691031,0.004267728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009089191,"about_ca_system_score_gemma":0.0004200777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010621,"about_ca_topic_score_gemma":0.001576196,"domain_scores_codex":[0.9994258,0.00004047506,0.0000364976,0.0001518691,0.000274375,0.0000710831],"domain_scores_gemma":[0.9998919,0.00001548569,0.00002223536,0.00002322809,0.00002996053,0.00001715769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025479,0.0001576426,0.0001856219,0.001761959,0.0000694104,0.0004273099,0.0001759969,0.0006964509,0.6977345,0.04789452,0.01886667,0.2319274],"study_design_scores_gemma":[0.00001527763,0.0001191308,0.0003202851,0.00004900232,0.00003261784,0.0006973001,0.00001656498,0.0008360877,0.564992,0.001517908,0.4313687,0.00003514185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.1139857,0.1783559,0.3322425,0.00183579,0.00230265,0.001439288,0.002158507,0.006939762,0.3607399],"genre_scores_gemma":[0.4127806,0.1401342,0.1629193,0.002211878,0.0006082315,0.001393771,0.003030956,0.0007257313,0.2761952],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.006515421,"threshold_uncertainty_score":0.02179623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008544337441018094,"score_gpt":0.2526938636458835,"score_spread":0.2441495262048654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}