{"id":"W1503639662","doi":"10.1111/j.1742-4658.2008.06495.x","title":"PCSK9 is phosphorylated by a Golgi casein kinase‐like kinase <i>ex vivo</i> and circulates as a phosphoprotein in humans","year":2008,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Proprotein convertase; PCSK9; Kexin; Phosphorylation; Endoplasmic reticulum; Casein kinase 2; Furin; Kinase; Phosphoprotein; Biology; Golgi apparatus; Protein kinase A; Biochemistry; LDL receptor; Cell biology; Chemistry; Cyclin-dependent kinase 2; Cholesterol; Lipoprotein; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008786214,0.0003843161,0.0007865033,0.0002311912,0.0004106918,0.00007410846,0.0001489087,0.0002662698,0.0009560421],"category_scores_gemma":[0.00007222671,0.000334825,0.0003716879,0.0004960849,0.0001553902,0.0002070221,0.00006233106,0.001059008,0.00009244189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002978322,"about_ca_system_score_gemma":0.0004656422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003081314,"about_ca_topic_score_gemma":0.00005229254,"domain_scores_codex":[0.9970303,0.0001521379,0.0006933227,0.0005133342,0.0008623598,0.000748609],"domain_scores_gemma":[0.9983354,0.00002467147,0.0002079876,0.0005356043,0.0001817148,0.0007146107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003972458,0.004304147,0.1978483,0.001492591,0.003021186,0.1130794,0.02037516,0.00004507717,0.1659072,0.000209374,0.3710904,0.1186547],"study_design_scores_gemma":[0.02779781,0.002875363,0.07806554,0.001618308,0.0005571291,0.06389401,0.001649439,0.0003366372,0.1237997,0.0006488559,0.6970595,0.001697714],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575527,0.03856863,0.0000668656,0.001828869,0.0002467944,0.000753379,0.00002764366,0.00005402292,0.0009011195],"genre_scores_gemma":[0.9867573,0.006675512,0.0002772688,0.003248379,0.0005411044,0.00003675491,0.0000179554,0.00008001224,0.002365681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3259691,"threshold_uncertainty_score":0.9999572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235361360377333,"score_gpt":0.2440097670278132,"score_spread":0.2316561534240399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}