{"id":"W1503938960","doi":"10.1046/j.1365-2958.2003.03697.x","title":"Large‐scale essential gene identification in <i>Candida albicans</i> and applications to antifungal drug discovery","year":2003,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":523,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto; Concordia University; Eli Lilly (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund","keywords":"Candida albicans; Biology; Corpus albicans; Gene; Antifungal drug; Computational biology; Phenotype; Genetics; Virulence; Mutant; Phenotypic screening","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004548847,0.0004621937,0.0004698282,0.0009095932,0.0002481818,0.0005165878,0.0005456068,0.0003211863,0.0008453469],"category_scores_gemma":[0.000345485,0.0002342028,0.000624428,0.0005443839,0.0003665424,0.0002353065,0.0005068217,0.0007821911,0.0006308684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004510122,"about_ca_system_score_gemma":0.0004760108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001430599,"about_ca_topic_score_gemma":0.002520174,"domain_scores_codex":[0.9998021,0.00002171402,0.00002721762,0.00004976138,0.00007019031,0.00002917689],"domain_scores_gemma":[0.9997458,0.00005850984,0.00007521457,0.00004450327,0.00003362117,0.00004237737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003695219,0.000009492735,0.0002607474,0.00003374655,0.000003153747,0.0000462696,0.000009343228,0.00008619875,0.9969867,0.00009864723,0.00006316258,0.002365536],"study_design_scores_gemma":[0.00001554023,0.0001430156,0.0102568,0.00001763176,0.0000443289,0.0008963064,0.00004912675,0.002005872,0.9800136,0.0003106973,0.006226574,0.00002047144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8765659,0.005802677,0.1026291,0.0006575576,0.0001093147,0.0005098995,0.009333098,0.001038066,0.003354353],"genre_scores_gemma":[0.847019,0.005486992,0.1253588,0.0003221991,0.00003242587,0.0002207052,0.01758227,0.0003293652,0.003648189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430599,"threshold_uncertainty_score":0.003272355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003945229214726357,"score_gpt":0.2486268039809375,"score_spread":0.2446815747662111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}