{"id":"W1503938960","doi":"10.1046/j.1365-2958.2003.03697.x","title":"Large‐scale essential gene identification in <i>Candida albicans</i> and applications to antifungal drug discovery","year":2003,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":523,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto; Concordia University; Eli Lilly (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund","keywords":"Candida albicans; Biology; Corpus albicans; Gene; Antifungal drug; Computational biology; Phenotype; Genetics; Virulence; Mutant; Phenotypic screening","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002933427,0.0001384855,0.0002679254,0.0001090942,0.0000687744,0.00002425243,0.00007650251,0.0001018769,0.00004806151],"category_scores_gemma":[0.00005073684,0.0001345122,0.00006508963,0.0002589241,0.0001086926,0.00005316411,0.00004158356,0.0001457258,0.00003944175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005363655,"about_ca_system_score_gemma":0.00007560879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002638577,"about_ca_topic_score_gemma":0.0002662986,"domain_scores_codex":[0.99871,0.0001190536,0.000298587,0.0005067868,0.00005457205,0.0003109755],"domain_scores_gemma":[0.9993944,0.00002444801,0.00005057197,0.0003800663,0.00005566448,0.00009489969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006554168,0.000166002,0.03067721,0.00003269432,0.00001684149,0.00002511033,0.0001508948,0.000003276544,0.9676813,0.0008059378,0.0002623198,0.0001128019],"study_design_scores_gemma":[0.001415561,0.00007110988,0.05048611,0.00003256797,0.00007271535,0.0001415532,0.0004505396,0.000006527414,0.911752,0.0003168033,0.0349777,0.0002768071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9508891,0.0007372975,0.04675052,0.0003374571,0.00006638441,0.0006392265,0.0000725763,0.00001940105,0.0004880186],"genre_scores_gemma":[0.997022,0.00005287766,0.0006717454,0.0009111837,0.00002702481,0.00007203108,0.0001793088,0.00001658338,0.001047184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05592936,"threshold_uncertainty_score":0.5485248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003945229214726357,"score_gpt":0.2486268039809375,"score_spread":0.2446815747662111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}