{"id":"W1503940032","doi":"10.1046/j.1432-1327.2001.02041.x","title":"Drug transport by reconstituted P‐glycoprotein in proteoliposomes","year":2001,"lang":"en","type":"article","venue":"European Journal of Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Chemistry; P-glycoprotein; Lipid bilayer; Substrate (aquarium); Biophysics; Efflux; ATP hydrolysis; ATP-binding cassette transporter; Membrane; Mediated transport; Passive transport; Kinetics; Membrane transport protein; Membrane transport; Vanadate; Bilayer; ATPase; Transporter; Biochemistry; Membrane protein; Enzyme; Multiple drug resistance; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005336107,0.0008369228,0.00095733,0.0003227791,0.0002602529,0.0008157588,0.0007358718,0.0006268498,0.0007318789],"category_scores_gemma":[0.0004117869,0.0004167016,0.0006002414,0.0003194173,0.000408391,0.0008682746,0.000530999,0.001266561,0.0008762673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001221152,"about_ca_system_score_gemma":0.0005179037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001986085,"about_ca_topic_score_gemma":0.001264779,"domain_scores_codex":[0.9994494,0.0001181133,0.00007127751,0.0001492767,0.0001078081,0.000104064],"domain_scores_gemma":[0.9997548,0.00006828563,0.00006769403,0.00003473548,0.00004006502,0.00003433545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001264815,0.00003215843,0.00007037256,0.00006931095,0.00002047072,0.00005722002,0.00004208306,0.0002713913,0.998571,0.000225994,0.00004969195,0.0004636685],"study_design_scores_gemma":[0.00006598223,0.0001778188,0.0004683671,0.00001344324,0.00003573157,0.00008079171,0.00002738934,0.006438777,0.990918,0.0001560158,0.001601895,0.00001580298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709755,0.001919191,0.02297229,0.0004705553,0.0001471776,0.0001627977,0.001279637,0.000631045,0.001441725],"genre_scores_gemma":[0.9805686,0.001597014,0.01235322,0.0001492228,0.00005247003,0.0001675279,0.002392379,0.000185635,0.002533867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001986085,"threshold_uncertainty_score":0.008860111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006253383329981905,"score_gpt":0.2080148670277214,"score_spread":0.2017614836977395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}