{"id":"W1504162296","doi":"10.1002/9780470372531.ch3","title":"Drug‐Associated Mitochondrial Toxicity","year":2008,"lang":"en","type":"other","venue":"","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Steatohepatitis; Steatosis; Endogeny; Oxidative stress; Drug; Toxicity; Mitochondrial toxicity; Liver toxicity; Pharmacology; Chemistry; Liver injury; Mitochondrion; Fatty liver; Biology; Biochemistry; Medicine; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00003244175,0.0002597617,0.0002530694,0.00006133541,0.00003380974,0.00001086274,0.0002454143,0.0004505102,0.002820981],"category_scores_gemma":[0.00005846325,0.0002391198,0.0001512509,0.00006205067,0.00008345287,3.276777e-7,0.00008834065,0.00008059493,0.0001950368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001823456,"about_ca_system_score_gemma":0.00008837456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001853974,"about_ca_topic_score_gemma":0.001196921,"domain_scores_codex":[0.9989403,0.00005514324,0.0001534805,0.0004314867,0.0001612071,0.0002583651],"domain_scores_gemma":[0.9993384,0.000002915626,0.0001090843,0.0004387781,0.00002393295,0.00008681957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009731333,0.00006336976,0.000101109,0.000005508903,0.00009966631,0.000001700034,0.000007144507,7.098545e-7,0.005993404,0.00001971015,0.9931613,0.0005366796],"study_design_scores_gemma":[0.0005765497,0.0000267285,0.0001078506,0.00001099874,0.00002354417,0.000002175016,0.000008056471,9.30672e-7,0.006236409,0.00001246381,0.9926852,0.000309122],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.001932267,0.004144375,0.0003213842,0.00004625032,0.001110829,0.0002697633,0.0001053817,0.00006903826,0.9920007],"genre_scores_gemma":[0.0006549779,0.002901955,0.0007225903,0.0004341087,0.001091984,0.00001786336,0.0006604714,0.0002842223,0.9932318],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.002625944,"threshold_uncertainty_score":0.9980906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005455787347097223,"score_gpt":0.2186501023577668,"score_spread":0.2131943150106696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}