{"id":"W1504251699","doi":"10.1111/j.1365-2567.2010.03359.x","title":"Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action","year":2010,"lang":"en","type":"article","venue":"Immunology","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Engineering and Physical Sciences Research Council; Wellcome Trust","keywords":"Phototoxicity; Photodynamic therapy; Conjugate; Photosensitizer; Porphyrin; Chemistry; Antibody; In vivo; Monoclonal antibody; In vitro; Mechanism of action; Molecular biology; Cancer research; Biophysics; Biochemistry; Photochemistry; Medicine; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002575824,0.0003208875,0.0002248254,0.0001716308,0.0001195731,0.0003133549,0.0002650913,0.0004705113,0.0006905461],"category_scores_gemma":[0.000199815,0.0001577831,0.0001658239,0.0001937101,0.000198253,0.0002657489,0.0001847088,0.0003777902,0.0002301843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004958677,"about_ca_system_score_gemma":0.000212117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002317381,"about_ca_topic_score_gemma":0.0002089614,"domain_scores_codex":[0.9998443,0.00003104079,0.00001076609,0.0000353945,0.00003859097,0.00003988546],"domain_scores_gemma":[0.9998907,0.00001785324,0.0000382525,0.00001216042,0.00001594918,0.00002509723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009587163,0.00002939083,0.0001051482,0.00006138453,0.000005628705,0.00004262432,0.00001062241,0.0001183409,0.9942527,0.0002385556,0.0000308785,0.005008822],"study_design_scores_gemma":[0.00001638551,0.000351001,0.0007231975,0.000002777085,0.00001218834,0.0004330669,0.000003827932,0.0003812406,0.9960982,0.0000369706,0.00193651,0.00000457725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765189,0.007231258,0.01384782,0.0001450604,0.00002942304,0.0001085737,0.00008881745,0.000102166,0.001927938],"genre_scores_gemma":[0.9904832,0.001203439,0.006397031,0.0000579453,0.000007086305,0.00006416309,0.00007893852,0.00001159793,0.001696665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006905461,"threshold_uncertainty_score":0.003597796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01545927452987495,"score_gpt":0.3342170536900351,"score_spread":0.3187577791601601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}