{"id":"W1504365021","doi":"10.1038/cdd.2015.88","title":"Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Centre Hospitalier Universitaire de Québec; Beckman Research Institute, City of Hope; American Society of Hematology; St. Jude Children's Research Hospital; National Heart, Lung, and Blood Institute; University of Minnesota; Moffitt Cancer Center","keywords":"Autophagy; ULK1; Cell biology; Programmed cell death; Oxidative stress; Protein kinase A; DNA damage; Intracellular; Biology; Reactive oxygen species; Kinase; Chemistry; Apoptosis; Biochemistry; AMPK; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002905866,0.0003371559,0.0003542565,0.0003022683,0.0005153237,0.0007568716,0.0003120188,0.0003907871,0.005303595],"category_scores_gemma":[0.0003197101,0.000237238,0.0005183176,0.0002566509,0.000381613,0.0007595106,0.000474343,0.001014424,0.001279105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006827752,"about_ca_system_score_gemma":0.0003579215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003499105,"about_ca_topic_score_gemma":0.0005430456,"domain_scores_codex":[0.9997405,0.00004031946,0.00002776104,0.00005810971,0.00005423947,0.00007897909],"domain_scores_gemma":[0.9997864,0.00002421583,0.0000649911,0.00004112736,0.00003656367,0.00004671447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001499817,0.0001010113,0.0007264375,0.0002587605,0.00003212454,0.0001456354,0.00007560951,0.0001559018,0.9887672,0.0007663013,0.0008237074,0.006647413],"study_design_scores_gemma":[0.00006968581,0.0002875537,0.01206739,0.0000260457,0.00003462364,0.0005256275,0.0001650126,0.0007886465,0.9798434,0.0004097635,0.005770131,0.00001211189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661595,0.01124608,0.01022247,0.001272353,0.0003231163,0.00004762835,0.001521191,0.000591763,0.008616003],"genre_scores_gemma":[0.9933006,0.00138721,0.001319267,0.0001497498,0.00002640781,0.00002556623,0.0006622925,0.00003463018,0.003094344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005303595,"threshold_uncertainty_score":0.01774228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02812300230352254,"score_gpt":0.2785631308003013,"score_spread":0.2504401284967787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}