{"id":"W1504365021","doi":"10.1038/cdd.2015.88","title":"Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1","year":2015,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Centre Hospitalier Universitaire de Québec; Beckman Research Institute, City of Hope; American Society of Hematology; St. Jude Children's Research Hospital; National Heart, Lung, and Blood Institute; University of Minnesota; Moffitt Cancer Center","keywords":"Autophagy; ULK1; Cell biology; Programmed cell death; Oxidative stress; Protein kinase A; DNA damage; Intracellular; Biology; Reactive oxygen species; Kinase; Chemistry; Apoptosis; Biochemistry; AMPK; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001259595,0.0001568065,0.0002136718,0.0000952299,0.0000498763,0.00003467966,0.0000562254,0.00009088715,0.00007666254],"category_scores_gemma":[0.00005660223,0.0001315452,0.00003983848,0.0001123449,0.00001614688,0.0001248189,0.00003494317,0.0001036925,0.00005532099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006260483,"about_ca_system_score_gemma":0.000064489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000582166,"about_ca_topic_score_gemma":0.000005827488,"domain_scores_codex":[0.9990243,0.000111127,0.0001858943,0.000270782,0.0001936915,0.0002142092],"domain_scores_gemma":[0.9993663,0.00005288327,0.00006262428,0.0002014122,0.0000665039,0.0002503121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02021781,0.004896933,0.6418051,0.0005630503,0.0001366261,0.0002754007,0.04229503,0.00004344978,0.2818178,0.001828834,0.001826078,0.00429394],"study_design_scores_gemma":[0.006089318,0.001220322,0.7772909,0.0001462245,0.0001174127,0.000004294018,0.00103947,0.001018133,0.209179,0.002439123,0.00114633,0.0003094536],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962795,0.0004477023,0.0004153131,0.0001987995,0.00007728381,0.0004881494,0.0000171987,0.00004848919,0.00202751],"genre_scores_gemma":[0.9982358,0.00008426409,0.0005117463,0.0003619574,0.00006372288,0.000022134,0.00007889603,0.00001959364,0.0006219172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1354859,"threshold_uncertainty_score":0.5364258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02812300230352254,"score_gpt":0.2785631308003013,"score_spread":0.2504401284967787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}