{"id":"W1504680783","doi":"10.1038/nrmicro908","title":"Can innate immunity be enhanced to treat microbial infections?","year":2004,"lang":"en","type":"review","venue":"Nature Reviews Microbiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":298,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Innate immune system; Biology; Multicellular organism; Immunity; Immunology; TLR9; Toll-like receptor; Decoy; Microbiology; Receptor; Immune system; Genetics; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001087062,0.001352932,0.001947519,0.001035152,0.0002632597,0.001146664,0.0009944282,0.002134523,0.002869912],"category_scores_gemma":[0.001102641,0.0002661161,0.0004767228,0.0008841437,0.0008667351,0.002112677,0.0006637012,0.003888493,0.002215603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000476174,"about_ca_system_score_gemma":0.0006815311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003912749,"about_ca_topic_score_gemma":0.0009453312,"domain_scores_codex":[0.9998026,0.00003350177,0.00002814194,0.00003144626,0.0000776829,0.00002656256],"domain_scores_gemma":[0.9996233,0.0001680006,0.00004070302,0.00001757376,0.000103504,0.00004684192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000348651,0.0001221662,0.0001656674,0.005962916,0.00007402396,0.0003074963,0.00003718305,0.0003291532,0.006760421,0.005355867,0.05107724,0.9294592],"study_design_scores_gemma":[0.0001764728,0.0002391816,0.0006624459,0.001792191,0.0001392406,0.001840813,0.00006139271,0.0001662023,0.001871376,0.005916714,0.9871081,0.00002590745],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00021941,0.9943093,0.0005853155,0.001451354,0.001776208,0.000009081603,0.0000182543,0.00002150855,0.001609513],"genre_scores_gemma":[0.001661558,0.9913127,0.001015608,0.002108313,0.001646461,0.00002861724,0.00004166143,0.00000617425,0.002178975],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002869912,"threshold_uncertainty_score":0.009600759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02339976886653536,"score_gpt":0.3111361707593737,"score_spread":0.2877364018928383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}