{"id":"W1504690117","doi":"10.1111/ijs.12536","title":"Combined Lysis of Thrombus with Ultrasound and Systemic Tissue Plasminogen Activator for Emergent Revascularization in Acute Ischemic Stroke (Clotbust-ER): Design and Methodology of a Multinational Phase 3 Trial","year":2015,"lang":"en","type":"article","venue":"International Journal of Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Genentech; Bayer HealthCare; National Center for Theoretical Sciences; University of Calgary; Pfizer","keywords":"Medicine; Tissue plasminogen activator; Revascularization; Thrombus; Stroke (engine); Cardiology; Internal medicine; Ultrasound; Plasminogen activator; Clinical trial; Ischemic stroke; Intensive care medicine; Surgery; Radiology; Ischemia; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001154918,0.0001657462,0.0006330853,0.000462684,0.00001446582,0.00001195033,0.0001733963,0.00009630424,0.00001686084],"category_scores_gemma":[0.0008575226,0.0001359571,0.00009568132,0.0001051669,0.0001108493,0.0001796997,0.00005302582,0.0001482184,1.73322e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001655224,"about_ca_system_score_gemma":0.0002096288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002123419,"about_ca_topic_score_gemma":0.000001614489,"domain_scores_codex":[0.9979604,0.0001299906,0.0008714149,0.0001947076,0.0007085141,0.0001349592],"domain_scores_gemma":[0.9970984,0.0005826112,0.00100112,0.0001141319,0.001089675,0.0001140963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.08376357,0.0007235878,0.0102312,0.0001467229,0.0042039,0.00005215078,0.0008892528,0.0006767046,0.8958588,0.0001159187,0.001048594,0.002289626],"study_design_scores_gemma":[0.2291701,0.007885204,0.00294548,0.0006261073,0.002043532,0.001267013,0.001718897,0.003403859,0.7498739,0.00005771119,0.0007530121,0.0002550881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.826331,0.0002094259,0.1720399,0.0002554181,0.0002283545,0.000801751,0.00008993482,0.000003989819,0.00004019619],"genre_scores_gemma":[0.9103028,0.0001853356,0.08912843,0.00002895605,0.0001323066,0.00002516002,0.00004147088,0.00001826694,0.0001373087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1459848,"threshold_uncertainty_score":0.554417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06972682602090216,"score_gpt":0.3589860747161098,"score_spread":0.2892592486952077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}