{"id":"W1504690117","doi":"10.1111/ijs.12536","title":"Combined Lysis of Thrombus with Ultrasound and Systemic Tissue Plasminogen Activator for Emergent Revascularization in Acute Ischemic Stroke (Clotbust-ER): Design and Methodology of a Multinational Phase 3 Trial","year":2015,"lang":"en","type":"article","venue":"International Journal of Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Genentech; Bayer HealthCare; National Center for Theoretical Sciences; University of Calgary; Pfizer","keywords":"Medicine; Tissue plasminogen activator; Revascularization; Thrombus; Stroke (engine); Cardiology; Internal medicine; Ultrasound; Plasminogen activator; Clinical trial; Ischemic stroke; Intensive care medicine; Surgery; Radiology; Ischemia; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05043136,0.002520013,0.002744851,0.0008642421,0.001216316,0.00182625,0.001987892,0.00281468,0.005527555],"category_scores_gemma":[0.01860347,0.001083752,0.003512283,0.001131569,0.003011335,0.001540187,0.00147392,0.002714601,0.001124892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001761304,"about_ca_system_score_gemma":0.007765087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081675,"about_ca_topic_score_gemma":0.002065539,"domain_scores_codex":[0.9776733,0.0192004,0.0006068623,0.0009092623,0.0008329565,0.0007771676],"domain_scores_gemma":[0.9907284,0.003157466,0.002319921,0.001714217,0.0007557897,0.001324242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9448391,0.01743988,0.006962162,0.0007230662,0.002001872,0.00007446358,0.0002660953,0.001560059,0.001885464,0.0006811734,0.001453303,0.02211347],"study_design_scores_gemma":[0.8971113,0.09382863,0.003872164,0.00008010476,0.001042359,0.00004918994,0.00003450442,0.001309627,0.0005220409,0.0006075468,0.001511548,0.00003095679],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.6657229,0.003078572,0.01659885,0.002598562,0.0007968537,0.3036592,0.002795231,0.0003129069,0.004436895],"genre_scores_gemma":[0.5308226,0.001325482,0.04865869,0.003487325,0.0008800272,0.4107625,0.00164389,0.00008741066,0.002332116],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.05043136,"threshold_uncertainty_score":0.2667097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06972682602090216,"score_gpt":0.3589860747161098,"score_spread":0.2892592486952077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}