{"id":"W1504727591","doi":"10.1002/9780470515716.ch5","title":"Engineering Charge Selectivity in Alamethicin Channels","year":2007,"lang":"en","type":"article","venue":"Novartis Foundation symposium","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Alamethicin; Selectivity; Chemistry; Peptide; Ion channel; Membrane; Divalent; Ion; Membrane potential; Biophysics; Biochemistry; Organic chemistry; Lipid bilayer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005210493,0.0001305118,0.0001167594,0.0001105865,0.0000414985,0.00002788497,0.00009099324,0.0001589172,0.00007913085],"category_scores_gemma":[0.00005523775,0.0001357355,0.00004531424,0.0002319917,0.00001371705,0.00001155623,0.00003591935,0.0001337405,0.0000566726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003465049,"about_ca_system_score_gemma":0.00004145549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003141408,"about_ca_topic_score_gemma":0.00007473329,"domain_scores_codex":[0.9990498,0.0000223084,0.0002196437,0.0002941416,0.0001292638,0.0002848356],"domain_scores_gemma":[0.9996041,0.00001429801,0.00005252961,0.0002000593,0.00007094016,0.00005805647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003329873,0.00003567058,0.0046178,0.00001084007,0.000007665787,0.000002708075,0.00009303488,0.0001131714,0.9936925,0.0001672654,0.00005013555,0.001175946],"study_design_scores_gemma":[0.0004151409,0.00007115911,0.01003996,0.000007831126,0.000007431313,0.00001660573,0.000008094339,0.000142336,0.9686114,0.000006460343,0.02050856,0.0001649838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876238,0.0000110445,0.0102787,0.0002116593,0.0007400915,0.0001815291,0.000002029932,0.00002523033,0.0009259249],"genre_scores_gemma":[0.9982067,0.00001306747,0.000295826,0.0001740356,0.0005413039,0.00001291025,0.00008868908,0.00002002919,0.0006474697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02508103,"threshold_uncertainty_score":0.5535132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013681909700238,"score_gpt":0.2645813573686903,"score_spread":0.2544445382716879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}