{"id":"W1504727591","doi":"10.1002/9780470515716.ch5","title":"Engineering Charge Selectivity in Alamethicin Channels","year":2007,"lang":"en","type":"article","venue":"Novartis Foundation symposium","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Alamethicin; Selectivity; Chemistry; Peptide; Ion channel; Membrane; Divalent; Ion; Membrane potential; Biophysics; Biochemistry; Organic chemistry; Lipid bilayer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004152073,0.0002413138,0.0002333941,0.0001717701,0.0002002075,0.0005120302,0.0003632547,0.0003430672,0.0004022501],"category_scores_gemma":[0.0005014156,0.0001656795,0.0001374332,0.0001536731,0.0004383489,0.0004007944,0.0004341119,0.0007248199,0.0002112644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004239308,"about_ca_system_score_gemma":0.0002595875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003250885,"about_ca_topic_score_gemma":0.0004861782,"domain_scores_codex":[0.9996761,0.00007189862,0.00002772222,0.00005170368,0.0001112578,0.00006119131],"domain_scores_gemma":[0.9996786,0.00008372428,0.00007181582,0.00003702859,0.00005518006,0.00007365306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003136393,0.00001028974,0.00008260057,0.00001016921,0.000001900602,0.00002706559,0.00001212948,0.0001614384,0.9984583,0.0004442976,0.00001258911,0.0007477927],"study_design_scores_gemma":[0.00001611132,0.00007234179,0.0002679649,0.000002137778,0.000003733304,0.0001218094,0.00001557552,0.001866321,0.996332,0.0002022804,0.0010939,0.000005865313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839063,0.0003123035,0.01433447,0.0001175748,0.00003385172,0.0000455436,0.00006327797,0.00008818827,0.001098429],"genre_scores_gemma":[0.9909323,0.0002783531,0.007740111,0.00007220641,0.000009042244,0.00001789784,0.00007635978,0.00002930768,0.000844373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005120302,"threshold_uncertainty_score":0.003075898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013681909700238,"score_gpt":0.2645813573686903,"score_spread":0.2544445382716879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}