{"id":"W1505527163","doi":"10.1023/a:1023624922787","title":"Rapid induction of apoptosis in human keratinocytes with the photosensitizer QLT0074 via a direct mitochondrial action","year":2003,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"QLT (Canada)","funders":"","keywords":"Pyrrolidine dithiocarbamate; Cytochrome c; Apoptosis; Poly ADP ribose polymerase; HaCaT; Viability assay; Cell biology; Mitochondrion; Molecular biology; Chemistry; Programmed cell death; Caspase; Biology; Biochemistry; In vitro; Enzyme; Polymerase; NF-κB","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003463195,0.0002241459,0.0004578432,0.000237415,0.0001915921,0.00001967391,0.00008988209,0.0001037948,0.0001385269],"category_scores_gemma":[0.0001505057,0.0001432821,0.0001135656,0.000639538,0.0002537465,0.0001180895,0.00002656573,0.0003473703,0.000005361745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000166314,"about_ca_system_score_gemma":0.00007299647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006086479,"about_ca_topic_score_gemma":0.0001965869,"domain_scores_codex":[0.9982572,0.0002731862,0.0003067746,0.0003371971,0.0004732145,0.0003524411],"domain_scores_gemma":[0.9990312,0.0001868534,0.0001395918,0.0004068702,0.0001627002,0.00007274975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005965431,0.0002194172,0.0009811047,0.00004897695,0.0002637348,0.000001448584,0.0009680592,0.000008236311,0.9928535,0.0000348438,0.0007274891,0.003296665],"study_design_scores_gemma":[0.002396334,0.0006880795,0.005190286,0.00009978658,0.00009866311,0.00001318665,0.00113302,0.00002193775,0.9887607,0.00004479372,0.001399215,0.0001540061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948865,0.0001721901,0.00005307215,0.0006223748,0.0001598215,0.0009231751,0.000005395615,0.0000481597,0.003129354],"genre_scores_gemma":[0.9984903,0.0001868758,0.0004466333,0.0001344185,0.0001194314,0.0001948793,0.00001268831,0.00003342657,0.0003813762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004209181,"threshold_uncertainty_score":0.5842876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02682172080978966,"score_gpt":0.2993308204426785,"score_spread":0.2725090996328888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}