{"id":"W1506028353","doi":"10.1046/j.1432-1327.2000.01767.x","title":"Examining the zinc binding site of the amyloid‐β peptide","year":2000,"lang":"en","type":"article","venue":"European Journal of Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Occupational Cancer Research Centre","funders":"","keywords":"Peptide; Chemistry; Histidine; Circular dichroism; Zinc; Binding site; Fibril; Amyloid (mycology); Biophysics; Biochemistry; Beta sheet; Crystallography; Stereochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000495372,0.0001035033,0.0001548617,0.00002449969,0.0001032098,0.00001869123,0.000224872,0.0000158981,0.0004481321],"category_scores_gemma":[0.00009474043,0.00005178281,0.0001716796,0.0001428356,0.0001596329,0.00003579194,0.00005093534,0.000291338,0.00008602214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000343107,"about_ca_system_score_gemma":0.0001304132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001318486,"about_ca_topic_score_gemma":6.310992e-8,"domain_scores_codex":[0.9988583,0.0001433371,0.0003129613,0.00009605441,0.000410993,0.0001783293],"domain_scores_gemma":[0.9991536,0.00005490249,0.0002126925,0.0003068832,0.00009519215,0.0001767501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001863491,0.001105984,0.1497081,0.0003115545,0.0103069,0.004610303,0.001310775,0.00004038311,0.7454817,0.000003011673,0.02570242,0.05955533],"study_design_scores_gemma":[0.006349901,0.0009813361,0.3079652,0.002242211,0.001602227,0.003479689,0.001122248,0.0000328235,0.6668981,0.00001128842,0.009013453,0.0003015829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705238,0.002854938,0.000001443676,0.0003504617,0.00003035778,0.00005967298,0.00001297605,0.000004973498,0.02616134],"genre_scores_gemma":[0.9979,0.0002063002,0.00007991124,0.00008543068,0.0002616582,3.077759e-7,0.000003978202,0.00001953828,0.001442885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1582571,"threshold_uncertainty_score":0.4906732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02785937191767814,"score_gpt":0.268552244037511,"score_spread":0.2406928721198329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}