{"id":"W1506052843","doi":"10.4049/jimmunol.1403225","title":"Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10–Dependent Mechanism","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Child and Family Research Institute; Vancouver Coastal Health","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"FOXP3; Inflammasome; Cell biology; Acquired immune system; Adoptive cell transfer; Innate immune system; CD49b; Immune system; Chemistry; Biology; Immunology; T cell; Interleukin 21; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004997549,0.0009439322,0.0007751794,0.0004796142,0.0001874255,0.0006746359,0.0004677485,0.0005574333,0.002658668],"category_scores_gemma":[0.0003069695,0.000261339,0.0006429005,0.0003106111,0.0003912404,0.0003915807,0.0003105972,0.00186258,0.00133443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001853431,"about_ca_system_score_gemma":0.0003397522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003797954,"about_ca_topic_score_gemma":0.0007549757,"domain_scores_codex":[0.9991818,0.0001027997,0.0000780375,0.0001777116,0.0001543886,0.0003053014],"domain_scores_gemma":[0.9994214,0.00007138959,0.0002285158,0.00006253789,0.00005736079,0.0001588685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002934555,0.0001198545,0.0003964862,0.0001215613,0.00001078436,0.0001183773,0.00002895147,0.00006024805,0.9958504,0.00007671878,0.0001053399,0.002817794],"study_design_scores_gemma":[0.0003545387,0.004164494,0.01186202,0.00005664435,0.0001591441,0.003219932,0.0001636241,0.001281676,0.9696148,0.0002501627,0.008841401,0.00003153162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874403,0.004217196,0.003454628,0.0001960307,0.0001366419,0.0001638037,0.0009232459,0.0004361613,0.00303189],"genre_scores_gemma":[0.9881459,0.001720664,0.003618774,0.0002884731,0.0001300819,0.0001504309,0.001170188,0.0001158501,0.004659589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002658668,"threshold_uncertainty_score":0.008894145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01738793303781896,"score_gpt":0.2233193437320916,"score_spread":0.2059314106942726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}