{"id":"W1506568251","doi":"10.1002/pd.4194","title":"First‐trimester Down syndrome screening using additional serum markers with and without nuchal translucency and cell‐free DNA","year":2013,"lang":"en","type":"article","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of British Columbia; University of Calgary","funders":"","keywords":"Cell-free fetal DNA; Down syndrome; Nuchal translucency; Pregnancy-associated plasma protein A; Medicine; Obstetrics; Gestation; Nuchal Translucency Measurement; Gynecology; Fetus; First trimester; Aneuploidy; Pregnancy; Trisomy; Human chorionic gonadotropin; Prenatal diagnosis; Biology; Chromosome; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001051592,0.0003475324,0.0004076513,0.0001547797,0.0002313183,0.000124027,0.0001377551,0.0001630727,0.001602068],"category_scores_gemma":[0.0002069515,0.0002843867,0.00007201447,0.0001804762,0.0002541064,0.0005566151,0.0001675638,0.0002948024,0.00001806223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000328125,"about_ca_system_score_gemma":0.0000552797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005833983,"about_ca_topic_score_gemma":0.00004657294,"domain_scores_codex":[0.9982476,0.00004311658,0.0002815663,0.0005383684,0.0004102266,0.0004791328],"domain_scores_gemma":[0.9984297,0.0005551551,0.0000967439,0.00034422,0.00008922607,0.0004849302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003936169,0.000328423,0.9770864,0.0008150372,0.0002752125,0.0003023601,0.0003237211,0.00006485349,0.00007173963,0.00004706427,0.008186819,0.01210477],"study_design_scores_gemma":[0.004773886,0.0009279481,0.9823403,0.002648794,0.0004181416,0.001722411,0.0001692983,0.00386771,0.001498189,0.0001684819,0.0008780269,0.0005867897],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936684,0.001042441,0.0009477024,0.001119865,0.0000586503,0.0007843032,0.001257521,0.0001262104,0.0009949272],"genre_scores_gemma":[0.9786592,0.0002138727,0.0200605,0.0003290146,0.00007736108,0.0002378115,0.0002218663,0.00005429487,0.0001460461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0191128,"threshold_uncertainty_score":0.9999608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369389787099864,"score_gpt":0.2199526837190178,"score_spread":0.2062587858480192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}