{"id":"W1506568251","doi":"10.1002/pd.4194","title":"First‐trimester Down syndrome screening using additional serum markers with and without nuchal translucency and cell‐free DNA","year":2013,"lang":"en","type":"article","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of British Columbia; University of Calgary","funders":"","keywords":"Cell-free fetal DNA; Down syndrome; Nuchal translucency; Pregnancy-associated plasma protein A; Medicine; Obstetrics; Gestation; Nuchal Translucency Measurement; Gynecology; Fetus; First trimester; Aneuploidy; Pregnancy; Trisomy; Human chorionic gonadotropin; Prenatal diagnosis; Biology; Chromosome; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001209755,0.0004955232,0.0004440535,0.0004729583,0.00009329528,0.0003607059,0.000181084,0.0003326299,0.0005789103],"category_scores_gemma":[0.003434432,0.0001558543,0.0003414984,0.0002464543,0.000185102,0.0002185082,0.0001916706,0.0002349711,0.0001073997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003017785,"about_ca_system_score_gemma":0.0003036758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002416458,"about_ca_topic_score_gemma":0.002576966,"domain_scores_codex":[0.9991487,0.0003382326,0.0000421863,0.0001880589,0.0002183777,0.00006446473],"domain_scores_gemma":[0.9987096,0.0006426214,0.0003711696,0.00006296211,0.0001096859,0.00010405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003129899,0.0001847624,0.9358082,0.0001098027,0.0001846931,0.000330737,0.00009900772,0.0009465308,0.03162845,0.00004125694,0.00009251913,0.02744416],"study_design_scores_gemma":[0.0001472652,0.008565278,0.9488137,0.00004871709,0.0004696916,0.005265815,0.00008777015,0.007716813,0.02799205,0.00006772243,0.0008016329,0.00002353682],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997952,0.0007115643,0.0009177016,0.00003569499,0.000008204322,0.00001316038,0.00008897384,0.00001935967,0.000253244],"genre_scores_gemma":[0.9983277,0.0002134839,0.001153447,0.00002394816,0.000005440299,0.000007175472,0.0001210539,0.000002010725,0.0001457676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002416458,"threshold_uncertainty_score":0.006397843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369389787099864,"score_gpt":0.2199526837190178,"score_spread":0.2062587858480192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}