{"id":"W1507097934","doi":"10.1210/en.2012-1011","title":"Selective Cleavage of Human Sex Hormone-Binding Globulin by Kallikrein-Related Peptidases and Effects on Androgen Action in LNCaP Prostate Cancer Cells","year":2012,"lang":"en","type":"article","venue":"Endocrinology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Dihydrotestosterone; Sex hormone-binding globulin; Androgen; LNCaP; Biology; Androgen receptor; Proteolysis; Endocrinology; Internal medicine; Prostate cancer; Chemistry; Biochemistry; Hormone; Cancer; Medicine; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510514,0.0003206441,0.0002837513,0.0001843518,0.000206487,0.0002698661,0.0001715037,0.0001836712,0.001366976],"category_scores_gemma":[0.00007591446,0.000155047,0.000468987,0.0002930064,0.0001598714,0.0001156936,0.0001349185,0.0003946772,0.0004763467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003503331,"about_ca_system_score_gemma":0.0003628887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003231334,"about_ca_topic_score_gemma":0.004320807,"domain_scores_codex":[0.9998206,0.00003161624,0.00001658611,0.00002767329,0.00004734953,0.00005618661],"domain_scores_gemma":[0.9999557,0.000008464957,0.000008138776,0.000006964765,0.000009170372,0.00001163529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002122329,0.00008803537,0.0002830527,0.00006497248,0.00001480423,0.0001176128,0.00003176447,0.00009214121,0.9976401,0.00005686625,0.0001071026,0.001291253],"study_design_scores_gemma":[0.00002534411,0.0007573046,0.01150154,0.000004784551,0.00002566187,0.0003312978,0.00005753566,0.001018726,0.983314,0.00002755163,0.002926141,0.000009988602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917226,0.003527628,0.001415153,0.000100543,0.00005173812,0.00005157033,0.001026564,0.00007327832,0.002030875],"genre_scores_gemma":[0.9871125,0.002106384,0.001820952,0.00009520546,0.00001499133,0.00008003582,0.002174888,0.00001311964,0.006582042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003231334,"threshold_uncertainty_score":0.006425083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02185593404293199,"score_gpt":0.3357615613602231,"score_spread":0.3139056273172911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}