{"id":"W1507664670","doi":"10.1111/cge.12624","title":"Something old, something new: <i>TBK1</i>, a novel gene in known amyotrophic lateral sclerosis pathways","year":2015,"lang":"en","type":"letter","venue":"Clinical Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Amyotrophic lateral sclerosis; Exome sequencing; Exome; Genetics; Gene; TANK-binding kinase 1; Biology; Medicine; Neuroscience; Bioinformatics; Mutation; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.00371862,0.001198112,0.002956196,0.0008567485,0.0001716559,0.0002917383,0.001446362,0.004918171,0.0003217189],"category_scores_gemma":[0.002771353,0.00106306,0.001053041,0.001175002,0.0007129189,0.0001779012,0.001390875,0.01348815,0.0006683627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008465936,"about_ca_system_score_gemma":0.002408369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005181468,"about_ca_topic_score_gemma":0.00003872443,"domain_scores_codex":[0.988215,0.0008802891,0.003456703,0.002290322,0.002802305,0.002355439],"domain_scores_gemma":[0.9933384,0.001358368,0.0007602443,0.002386371,0.0007343775,0.001422259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005776744,0.001028537,0.01810208,0.0007257902,0.0006998319,0.002557646,0.001009073,0.0002572883,0.02510122,0.0000137806,0.9191025,0.0308246],"study_design_scores_gemma":[0.02159022,0.003999067,0.1193219,0.00434221,0.001073064,0.0002820122,0.00004045133,0.004439245,0.0007484799,0.002847101,0.8379165,0.003399737],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5910625,0.005915634,0.0006857691,0.3951194,0.00352732,0.002475222,0.0002243913,0.0003664905,0.0006232364],"genre_scores_gemma":[0.04074485,0.01152366,0.05856598,0.8284374,0.04352757,0.0001663215,0.001171903,0.0009894243,0.01487289],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5503177,"threshold_uncertainty_score":0.999182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2742506595748455,"score_gpt":0.3861948362769855,"score_spread":0.11194417670214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}