{"id":"W1507813580","doi":"10.1038/ejhg.2011.75","title":"Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders","year":2011,"lang":"en","type":"article","venue":"European Journal of Human Genetics","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Ontario Ministry of Research and Innovation; Medical Research Council; Canadian Institutes of Health Research; Hospital for Sick Children; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Fondation de France; Health Research Board; National Institute for Health and Care Research; Autism Speaks; Sick Kids Foundation; Ontario Genomics Institute; Fondation Orange; National Institutes of Health; Ontario Genomics; Fondation FondaMental; Koninklijke Nederlandse Akademie van Wetenschappen; Hussman Foundation; Genome Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Ontario Innovation Trust; University of Toronto","keywords":"Genome-wide association study; Biology; Autism; Genetics; Gene; Genetic association; Gene ontology; Single-nucleotide polymorphism; Computational biology; Biological pathway; Psychology; Genotype; Gene expression; Developmental psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007705145,0.0004327575,0.0005848714,0.00103552,0.001260908,0.000734441,0.0003401808,0.0005415035,0.002556629],"category_scores_gemma":[0.002411363,0.0001344668,0.0008511851,0.0005479021,0.0005362805,0.0002566913,0.0006218075,0.0005375686,0.0002125284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002602914,"about_ca_system_score_gemma":0.0004644051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004398576,"about_ca_topic_score_gemma":0.009598853,"domain_scores_codex":[0.9993444,0.000130198,0.00004556429,0.0002372581,0.0001229783,0.0001196991],"domain_scores_gemma":[0.9988115,0.0007174627,0.00008014905,0.0001390722,0.0001197449,0.0001320918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002240499,0.0003195035,0.4689743,0.0001673778,0.001094116,0.006456484,0.002431862,0.0007301079,0.4918545,0.0007571227,0.001604063,0.02337004],"study_design_scores_gemma":[0.00004468583,0.0001608453,0.9705613,0.00001725844,0.0004143998,0.006079023,0.0008546577,0.001663809,0.01772632,0.0006141036,0.0018373,0.00002628887],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970469,0.0001491649,0.001744056,0.00007934168,0.00001146821,0.00001176031,0.0004744031,0.00002742747,0.0004555582],"genre_scores_gemma":[0.9975061,0.00005516053,0.001446142,0.00004938101,0.000005611037,0.0000175864,0.0005905255,0.00001743439,0.000312022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004398576,"threshold_uncertainty_score":0.008745968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08239114988529213,"score_gpt":0.3197221161103393,"score_spread":0.2373309662250472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}