{"id":"W1508245019","doi":"10.1155/2015/408136","title":"The Potential Role of the NLRP3 Inflammasome as a Link between Mitochondrial Complex I Dysfunction and Inflammation in Bipolar Disorder","year":2015,"lang":"en","type":"review","venue":"Neural Plasticity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Canada Research Chairs; University of Toronto","funders":"","keywords":"Inflammasome; Pyrin domain; Inflammation; Reactive oxygen species; Mitochondrion; Mitochondrial ROS; Cell biology; Caspase 1; Bipolar disorder; Receptor; Chemistry; Biology; Neuroscience; Medicine; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002526936,0.0004293879,0.0007468032,0.001416393,0.0002466668,0.0005773875,0.0004134767,0.0007933234,0.002068408],"category_scores_gemma":[0.0003022991,0.0001427435,0.0003127246,0.001207494,0.0002952998,0.0007724903,0.0005069035,0.0009159236,0.0008735487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003650584,"about_ca_system_score_gemma":0.0007084406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006940779,"about_ca_topic_score_gemma":0.001331245,"domain_scores_codex":[0.9999251,0.00001172675,0.00001560915,0.00001309811,0.00002482114,0.000009679942],"domain_scores_gemma":[0.9999076,0.00003159688,0.00001851616,0.000002411737,0.00002694214,0.00001295661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001199858,0.00006234003,0.0004975201,0.01678151,0.00009694285,0.0009214525,0.0001388682,0.0002855287,0.004645659,0.004669806,0.02519132,0.9465891],"study_design_scores_gemma":[0.00003091268,0.0001648999,0.003156459,0.00446242,0.0001966273,0.007326287,0.0001757554,0.0001441573,0.001187208,0.004524371,0.9785993,0.00003167813],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002604897,0.9985693,0.0000972349,0.0002791793,0.0001279808,0.000002694818,0.00001203463,0.000004287963,0.0006468731],"genre_scores_gemma":[0.001219673,0.9978696,0.0001661162,0.0001416408,0.0001213076,0.000003699224,0.00001913683,8.421587e-7,0.0004578989],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002068408,"threshold_uncertainty_score":0.006919503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456893069823495,"score_gpt":0.2599412552075794,"score_spread":0.2453723245093444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}