{"id":"W1508752722","doi":"10.1111/bjd.12110","title":"Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study","year":2012,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":357,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Probity Medical Research","funders":"","keywords":"Secukinumab; Medicine; Psoriasis Area and Severity Index; Psoriasis; Placebo; Interleukin 17; Internal medicine; Dose; Randomized controlled trial; Gastroenterology; Concomitant; Clinical trial; Plaque psoriasis; Adverse effect; Immunology; Cytokine; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009934241,0.000274233,0.002108119,0.0003548141,0.0001971393,0.00001600843,0.0002355222,0.0002322416,0.0000616924],"category_scores_gemma":[0.0001034518,0.0001981337,0.0003392313,0.0002001819,0.0001663643,0.0001547336,0.00003869944,0.0002005897,0.000004785827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004722632,"about_ca_system_score_gemma":0.0001022198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001521168,"about_ca_topic_score_gemma":0.0001222168,"domain_scores_codex":[0.99618,0.001712036,0.001392618,0.0001897018,0.00009327147,0.0004323663],"domain_scores_gemma":[0.9976708,0.001218495,0.0007301437,0.0001948552,0.0001269917,0.00005866036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9473618,0.009339215,0.001603031,0.00002008684,0.003090951,0.0004376837,0.01483705,0.00004187812,0.0008525652,0.0001162797,0.00008972289,0.02220975],"study_design_scores_gemma":[0.9706026,0.001803318,0.001028076,0.00012517,0.001440793,0.01855746,0.002233473,0.000005753326,0.003710361,0.00002610247,0.0002952681,0.0001715988],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738658,0.0226848,0.00007318718,0.0002286662,0.0004671438,0.00247608,0.00003461183,0.000007623573,0.0001620851],"genre_scores_gemma":[0.9976514,0.001948613,0.00007707418,0.00003149748,0.00005910106,0.0001563948,0.00001649299,0.00001707427,0.00004238261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02378556,"threshold_uncertainty_score":0.8079658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137471321531433,"score_gpt":0.2808916357039868,"score_spread":0.2595169224886725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}