{"id":"W1508752722","doi":"10.1111/bjd.12110","title":"Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study","year":2012,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":357,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Probity Medical Research","funders":"","keywords":"Secukinumab; Medicine; Psoriasis Area and Severity Index; Psoriasis; Placebo; Interleukin 17; Internal medicine; Dose; Randomized controlled trial; Gastroenterology; Concomitant; Clinical trial; Plaque psoriasis; Adverse effect; Immunology; Cytokine; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002419641,0.00153832,0.003473337,0.0004796768,0.0004885328,0.0008747381,0.000955223,0.001810606,0.004545883],"category_scores_gemma":[0.001534325,0.000818541,0.001511162,0.0004126169,0.001442505,0.0008429002,0.0003209356,0.002034823,0.0008815155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004017496,"about_ca_system_score_gemma":0.001180213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003055266,"about_ca_topic_score_gemma":0.0007533025,"domain_scores_codex":[0.9991961,0.0003990636,0.00007174625,0.0001184693,0.0001158916,0.00009880692],"domain_scores_gemma":[0.998976,0.0002299919,0.0002243276,0.00009740837,0.000102961,0.0003692285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9291242,0.03132299,0.001082358,0.0007953273,0.000730846,0.00005498036,0.00007719747,0.0003807189,0.01503189,0.00008042754,0.0006933523,0.02062573],"study_design_scores_gemma":[0.8522834,0.1431397,0.002655799,0.00002572486,0.0002822567,0.00005155333,0.0000156061,0.0002777898,0.0007384001,0.00006158421,0.0004521479,0.00001595746],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881505,0.003233755,0.0008808245,0.0003254727,0.0002928714,0.005418514,0.0005357146,0.0001203709,0.001042075],"genre_scores_gemma":[0.9864355,0.002303475,0.002041223,0.0008519339,0.0003427724,0.005455513,0.0006856978,0.00002296029,0.001860854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004545883,"threshold_uncertainty_score":0.01520753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137471321531433,"score_gpt":0.2808916357039868,"score_spread":0.2595169224886725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}