{"id":"W1509827704","doi":"10.5772/28998","title":"Past and Future of Diagnosis and Therapy of Transmissible Spongiform Encephalopathy","year":2012,"lang":"en","type":"book-chapter","venue":"InTech eBooks","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Allard Foundation; Alberta Cancer Foundation; Ministry of Advanced Education, Government of Alberta","keywords":"Transmissible spongiform encephalopathy; Virology; Medicine; Bovine spongiform encephalopathy; Intensive care medicine; Internal medicine; Prion protein; Disease; Scrapie","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009417871,0.0001967807,0.0002474588,0.00005381324,0.00002484382,0.000006654649,0.0001085645,0.0003134575,0.00008190959],"category_scores_gemma":[0.000003108923,0.0001696332,0.0001136124,0.000005150645,0.0001579918,0.00000189955,0.00004965806,0.00009880125,3.872806e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003020688,"about_ca_system_score_gemma":0.00003343881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006457307,"about_ca_topic_score_gemma":0.000002310873,"domain_scores_codex":[0.9993491,0.000009104292,0.0002171122,0.0002104263,0.00009342566,0.0001208666],"domain_scores_gemma":[0.9994735,0.00001096707,0.0001525619,0.0002168689,0.00005996219,0.00008617159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001176477,0.00001137076,0.0003491918,0.0001140961,0.0000805048,0.000001246025,0.00008625662,5.908249e-9,0.2822309,0.000940897,0.00002372892,0.7160441],"study_design_scores_gemma":[0.0002386849,0.0002473028,0.0001188897,0.0001411531,0.00002820768,0.000008964244,0.00002015615,6.389097e-8,0.5317425,0.001344014,0.4659508,0.0001593088],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1403335,0.7879891,0.0003376919,0.0001033263,0.000201843,0.0009600713,0.0003755254,0.0000193698,0.06967957],"genre_scores_gemma":[0.8343261,0.1598628,0.000286293,0.00005917854,0.0004663831,0.00003357147,0.00003124677,0.00004407524,0.0048903],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7158848,"threshold_uncertainty_score":0.691744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01298120895956367,"score_gpt":0.2353986960738353,"score_spread":0.2224174871142716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}