{"id":"W1509956998","doi":"10.1046/j.1471-4159.2002.01122.x","title":"Inhibition of lipopolysaccharide‐induced cyclooxygenase‐2, tumor necrosis factor‐α and [Ca<sup>2+</sup>]<sub>i</sub> responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195","year":2002,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Microglia; Tumor necrosis factor alpha; Lipopolysaccharide; Cyclooxygenase; Chemistry; Agonist; Cytokine; Receptor; Pharmacology; Intracellular; MPTP; Endocrinology; Internal medicine; Inflammation; Biology; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015692,0.0004061396,0.0002703428,0.00011256,0.0001225845,0.0002263418,0.000157191,0.0001942987,0.0008899545],"category_scores_gemma":[0.0001622508,0.0001353697,0.0002346854,0.0001206325,0.0002030472,0.0001348996,0.0001716013,0.0003747224,0.0004189085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143399,"about_ca_system_score_gemma":0.0002589942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005558297,"about_ca_topic_score_gemma":0.000912698,"domain_scores_codex":[0.9998724,0.00002697893,0.00001475484,0.00001313184,0.00002372474,0.00004890955],"domain_scores_gemma":[0.9999356,0.000009370059,0.00002030887,0.000009530569,0.000009096873,0.00001614253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008044875,0.00005596869,0.00009564387,0.00009192203,0.00001021248,0.000101937,0.00002446908,0.0000564216,0.9968418,0.00005692999,0.00006384192,0.001796339],"study_design_scores_gemma":[0.0002146566,0.001610631,0.004628673,0.00001712901,0.00002737224,0.0006040432,0.00003460981,0.0006521306,0.9898632,0.00007914117,0.002261358,0.000007109031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890871,0.007156642,0.001241172,0.0001562034,0.00004398395,0.00007141294,0.0003803739,0.00009035625,0.00177274],"genre_scores_gemma":[0.9927141,0.002985319,0.00193431,0.00007017196,0.00002757219,0.0001687741,0.0006058629,0.00001142482,0.001482454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008899545,"threshold_uncertainty_score":0.002977192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01468269385447574,"score_gpt":0.2372312013003471,"score_spread":0.2225485074458713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}