{"id":"W1510147084","doi":"10.4049/jimmunol.179.2.1210","title":"The Human Endogenous Retrovirus Envelope Glycoprotein, Syncytin-1, Regulates Neuroinflammation and Its Receptor Expression in Multiple Sclerosis: A Role for Endoplasmic Reticulum Chaperones in Astrocytes","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University; University of Alberta; University of Calgary","funders":"","keywords":"Endoplasmic reticulum; Neuroinflammation; Astrocyte; Biology; Microglia; Downregulation and upregulation; Cell biology; Oligodendrocyte; Neurodegeneration; Glial fibrillary acidic protein; Molecular biology; Immunology; Central nervous system; Endocrinology; Internal medicine; Myelin; Gene; Medicine; Biochemistry; Inflammation; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001536768,0.0001147992,0.0001668203,0.0001014681,0.0002403207,0.00002181556,0.0002882876,0.0001105956,0.000002341724],"category_scores_gemma":[0.0006639303,0.00007098093,0.00004538337,0.00007714723,0.0001168687,0.00001421903,0.0001097032,0.0002511754,9.801456e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002999095,"about_ca_system_score_gemma":0.00004626822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000333781,"about_ca_topic_score_gemma":0.0002322076,"domain_scores_codex":[0.9987373,0.0002181682,0.0004524468,0.0001242512,0.0001113554,0.0003564142],"domain_scores_gemma":[0.9991888,0.0002211365,0.0002705697,0.000168515,0.0001146831,0.00003622684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001743534,0.00002535894,0.001031181,0.00000807472,0.00002100726,0.000003300715,0.0002195698,0.00003549681,0.9932539,0.00002048244,0.00001101872,0.003627013],"study_design_scores_gemma":[0.001535345,0.0008960086,0.01463345,0.00008456978,0.00000506084,0.0001328549,0.0007613634,0.00008763142,0.981378,0.00004533229,0.0003702832,0.00007012838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898305,0.009430017,0.00008253002,0.0002173308,0.00006299926,0.0003564043,0.000001857551,0.000002523777,0.00001583347],"genre_scores_gemma":[0.9966431,0.002921113,0.0002211865,0.00001569082,0.00008765449,0.00001452716,0.000003744932,0.00001451772,0.00007848612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01360227,"threshold_uncertainty_score":0.2894518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194708046091897,"score_gpt":0.2372463400489177,"score_spread":0.2152992595879988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}