{"id":"W1510147084","doi":"10.4049/jimmunol.179.2.1210","title":"The Human Endogenous Retrovirus Envelope Glycoprotein, Syncytin-1, Regulates Neuroinflammation and Its Receptor Expression in Multiple Sclerosis: A Role for Endoplasmic Reticulum Chaperones in Astrocytes","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University; University of Alberta; University of Calgary","funders":"","keywords":"Endoplasmic reticulum; Neuroinflammation; Astrocyte; Biology; Microglia; Downregulation and upregulation; Cell biology; Oligodendrocyte; Neurodegeneration; Glial fibrillary acidic protein; Molecular biology; Immunology; Central nervous system; Endocrinology; Internal medicine; Myelin; Gene; Medicine; Biochemistry; Inflammation; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168668,0.000328629,0.0001740559,0.0001873203,0.0001351686,0.0002463092,0.0001036813,0.0002163643,0.0004305446],"category_scores_gemma":[0.00007878857,0.0001011703,0.0001800426,0.0001051611,0.0002285062,0.0001762203,0.0001170863,0.0003356154,0.0001691694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000242032,"about_ca_system_score_gemma":0.0001441991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003019175,"about_ca_topic_score_gemma":0.0004360381,"domain_scores_codex":[0.9999207,0.00001459611,0.000007496808,0.0000170694,0.00002310272,0.00001695966],"domain_scores_gemma":[0.9999546,0.000004770333,0.00001480985,0.000003975145,0.000009269933,0.00001258025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000662255,0.00001065293,0.0001275429,0.00001302425,0.000002382462,0.00004470136,0.000006690253,0.00001681573,0.9993147,0.00002475801,0.000007744401,0.0003647646],"study_design_scores_gemma":[0.00003364333,0.0004821497,0.02231544,0.00001076923,0.00003997546,0.000765015,0.00006999298,0.00134364,0.9732776,0.0001361217,0.001520005,0.000005587109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941287,0.003813991,0.001317523,0.00009081993,0.00001599243,0.00001229143,0.00008420259,0.00003121108,0.0005053119],"genre_scores_gemma":[0.9960019,0.001896832,0.0008811447,0.00004552415,0.000009087013,0.00001838679,0.0001330448,0.000006875348,0.00100708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004305446,"threshold_uncertainty_score":0.001756012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194708046091897,"score_gpt":0.2372463400489177,"score_spread":0.2152992595879988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}