{"id":"W1510315517","doi":"10.1002/ijc.29025","title":"Clinical importance of risk variants in the dihydropyrimidine dehydrogenase gene for the prediction of early‐onset fluoropyrimidine toxicity","year":2014,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"DPYD; Medicine; Toxicity; Internal medicine; Dihydropyrimidine dehydrogenase; Relative risk; Retrospective cohort study; Prospective cohort study; Gastroenterology; Pharmacogenetics; Surgery; Chemotherapy; Oncology; Fluorouracil; Confidence interval; Biology; Genetics; Genotype; Gene; Thymidylate synthase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007351685,0.0003093846,0.0003318511,0.0004102462,0.0002139404,0.0004502223,0.000268172,0.0005277407,0.001410694],"category_scores_gemma":[0.004545391,0.0001721288,0.0002968269,0.0004205862,0.0002939594,0.0001795699,0.000221845,0.0005769735,0.0001751303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001017535,"about_ca_system_score_gemma":0.0002168639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001221902,"about_ca_topic_score_gemma":0.001258853,"domain_scores_codex":[0.9994621,0.0002160469,0.00005317587,0.0001272619,0.00009219741,0.00004925056],"domain_scores_gemma":[0.9965813,0.00181995,0.0008292112,0.0001995971,0.0001642887,0.0004057151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001992418,0.00001173224,0.9965022,0.000004298814,0.00002683919,0.0002652282,0.0000206682,0.00009255588,0.0009455499,0.00001126555,0.00002816873,0.00189233],"study_design_scores_gemma":[0.00002433909,0.0001880675,0.9959473,0.000006789201,0.00007058094,0.002113426,0.00004852637,0.0009752774,0.0003539578,0.00007330792,0.0001919632,0.000006407554],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991218,0.000353478,0.0001863441,0.00003635993,0.000004432385,0.000004868464,0.00006178247,0.000003546165,0.0002273588],"genre_scores_gemma":[0.9997278,0.00003918553,0.0001259508,0.00001031546,0.000008298168,0.000001464235,0.00004076333,0.000001705686,0.00004450438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001410694,"threshold_uncertainty_score":0.004719257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03641762488755532,"score_gpt":0.3689768865698564,"score_spread":0.3325592616823011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}