{"id":"W1511076563","doi":"10.1113/expphysiol.2012.068338","title":"The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin‐1β","year":2012,"lang":"en","type":"article","venue":"Experimental Physiology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Heart and Stroke Foundation of Canada","keywords":"Inflammasome; Inflammation; Calcineurin; Diabetic cardiomyopathy; Heart failure; Caspase 1; Anakinra; Medicine; Cardiac function curve; Transgene; Cardiomyopathy; Cytokine; Immunology; Interleukin; Internal medicine; Biology; Disease; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006335618,0.0004569608,0.0005181632,0.0003015237,0.0001399524,0.0006760951,0.0003521302,0.0006513862,0.001715874],"category_scores_gemma":[0.0003160528,0.0001314879,0.0005222962,0.0002221857,0.0007029096,0.001128944,0.0003448675,0.001608852,0.0004521109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001915494,"about_ca_system_score_gemma":0.0002518383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007307553,"about_ca_topic_score_gemma":0.0001128648,"domain_scores_codex":[0.9998078,0.00004008862,0.00003119236,0.00004409912,0.000044289,0.00003247148],"domain_scores_gemma":[0.9995782,0.00007366139,0.0001327982,0.00004416311,0.00008187031,0.00008944271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003829109,0.001002242,0.0074946,0.006063301,0.0002444255,0.005198083,0.0007376099,0.0002495991,0.8729078,0.006388159,0.006344031,0.08954106],"study_design_scores_gemma":[0.001890711,0.01283929,0.3021529,0.004471679,0.001707258,0.03151949,0.003478186,0.003487306,0.4195754,0.02797089,0.1906477,0.0002593176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5922297,0.361644,0.01011815,0.0230047,0.003038749,0.0001552691,0.00101893,0.0003808097,0.008409634],"genre_scores_gemma":[0.809708,0.1698533,0.003493551,0.005571538,0.004477295,0.0001977097,0.0004739623,0.00005187104,0.00617277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001715874,"threshold_uncertainty_score":0.005740166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006711770145653936,"score_gpt":0.2495265130252859,"score_spread":0.242814742879632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}