{"id":"W1511076563","doi":"10.1113/expphysiol.2012.068338","title":"The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin‐1β","year":2012,"lang":"en","type":"article","venue":"Experimental Physiology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":179,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Heart and Stroke Foundation of Canada","keywords":"Inflammasome; Inflammation; Calcineurin; Diabetic cardiomyopathy; Heart failure; Caspase 1; Anakinra; Medicine; Cardiac function curve; Transgene; Cardiomyopathy; Cytokine; Immunology; Interleukin; Internal medicine; Biology; Disease; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001245759,0.0002153755,0.0001923834,0.00002559301,0.0001807892,0.00002027323,0.0002081715,0.0001510705,0.00002769605],"category_scores_gemma":[0.00002900843,0.0001623086,0.0001515216,0.00007691115,0.0002189151,0.00002920904,0.0002183432,0.0001457053,0.00003907653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004341888,"about_ca_system_score_gemma":0.00002724982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005777398,"about_ca_topic_score_gemma":0.00001049111,"domain_scores_codex":[0.9987252,0.0001528898,0.0002462931,0.0002730494,0.0000903917,0.0005121232],"domain_scores_gemma":[0.999502,0.00001288808,0.00007609286,0.0003447511,0.00002418229,0.00004007908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002854221,0.00004196198,0.002057229,0.000003630551,0.00006348508,7.148254e-7,0.0007548368,0.00001966339,0.9954293,0.0004985235,0.0003419416,0.0005033077],"study_design_scores_gemma":[0.001299291,0.0005040587,0.08214022,0.000006273985,0.000009016808,0.00002343652,0.002403153,0.00001984284,0.8896931,0.0003283126,0.02323611,0.000337151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917017,0.004979963,0.000007309506,0.00005395947,0.001359752,0.0002604617,0.00000280011,0.00001527119,0.001618782],"genre_scores_gemma":[0.9985207,0.00008637784,0.00003189084,0.0001663192,0.0008028962,0.000113009,0.0001332347,0.00002487387,0.0001207456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1057361,"threshold_uncertainty_score":0.6618752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006711770145653936,"score_gpt":0.2495265130252859,"score_spread":0.242814742879632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}