{"id":"W151193486","doi":"10.1016/b978-0-12-417158-9.00008-x","title":"Turning ON Caspases with Genetics and Small Molecules","year":2014,"lang":"en","type":"review","venue":"Methods in enzymology on CD-ROM/Methods in enzymology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Chronic Disease Prevention and Health Promotion; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Mental Health; National Cancer Institute; National Science Foundation; National Institutes of Health; Government of Canada; Ellison Medical Foundation","keywords":"Caspase; Proteases; Biology; Cell biology; Intrinsic apoptosis; Apoptosis; Small molecule; Phenotype; Neuroscience; Programmed cell death; Genetics; Biochemistry; Gene; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009156452,0.001358869,0.001377781,0.001772834,0.0003302368,0.001296534,0.001114852,0.001425633,0.00354424],"category_scores_gemma":[0.0009044653,0.0004994093,0.0005463205,0.001631648,0.001444362,0.002782827,0.001260849,0.004377575,0.003955531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001002398,"about_ca_system_score_gemma":0.0009006839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004544014,"about_ca_topic_score_gemma":0.0009692154,"domain_scores_codex":[0.9996597,0.00005010608,0.0000360818,0.00005220623,0.0001583214,0.00004349557],"domain_scores_gemma":[0.9997053,0.0001469742,0.00003537567,0.00001991467,0.00006461165,0.00002783283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008045847,0.00008293835,0.00008446366,0.008000062,0.00004676468,0.000157711,0.00006456055,0.000413209,0.007445022,0.02497968,0.04175781,0.9168873],"study_design_scores_gemma":[0.00002330163,0.00004909137,0.0001298374,0.0006875511,0.00002476177,0.0003478267,0.00002010995,0.00009100883,0.002916677,0.00584137,0.9898524,0.00001621736],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002434,0.993236,0.00171507,0.0008627173,0.0008576967,0.00001118408,0.00002314092,0.00004077554,0.003010008],"genre_scores_gemma":[0.002195512,0.9906092,0.001673818,0.001051991,0.0005631601,0.00002564072,0.00006446937,0.00001469463,0.003801612],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00354424,"threshold_uncertainty_score":0.01185668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07529992138975483,"score_gpt":0.429885175549056,"score_spread":0.3545852541593012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}